Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images23Cancer, such as biological process that goes beyond the laws of development and cellular growth, requires relocation process and investigate molecular mechanisms that lead to uncontrolled cell division, genomic instability and tumor development. The identification of these new patterns of growth and development can be very important to understand and combat processes tumorogĂ©nesis.1 It appears from research such as referenced here, the Cdc6 and other cellular components are joined, forming complexes prerreplicativos before initiated DNA duplication. Read the rest of this entry »

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  • images41One of the tenets associated with cancer advocates that the inactivation of oncogenes leads to remission of the tumors, implying that oncogenes would be the real Achilles heel of cancer. This model has kept the oncogenes as a therapeutic target clear and agreed with the certainty that in human cancer all cancer cells, irrespective of the existing cellular heterogeneity in the tumor, carry the same genetic lesions Oncogenetics home. This view may now be questioned from a study on the effect of BCR-ABL oncogene in the development of cancer in an animal model of oncogene expression restricted to stem cells. Read the rest of this entry »

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  • stem28lf1_196556gm-aThe loss of cell polarity and cancer are two processes are related, although there is no direct evidence to explain this correlation. In stem cells, loss of cell polarity and consequently, the alteration of the division process could produce cells unable to respond to the mechanisms controlling the proliferation and lead to cancer cells. Research by Emmanuel Caussinus and Cayetano Gonzalez has raised two related questions: if the stem cells can become cancerous cells and if this process may be related to loss of polarity.

    To answer these questions have been developed in Drosophila melanogaster larval neuroblasts with mutations in genes that control asymmetric cell division (raps, look, numb or pros) and have observed their proliferative capacity after transplanting in the abdomen of adult flies. Read the rest of this entry »

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  • a1The cover image of the international edition of the February 13 issue of the journal Angewandte Chemie German represents a new form of DNA helices formed by three researchers who have described CSIC, Institute of Biomedical Research of the PCB and the University of Birmingham, in a collaboration that has found a surprising structure almost by chance, while trying to test the effectiveness of a drug as a therapeutic agent against DNA targets. Read the rest of this entry »

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