Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images66VRK proteins are a group of serine-threonine kinases involved in the regulation of p53 and other transcription factors involved in cellular stress responses. Most recently, Pedro Lazo’s laboratory at the Cancer Research Center of Salamanca has identified new aspects of the biology of two members of the family. The VRK1 kinase is required to carry out the cell cycle. VRK1 gene expression when standing stop the cycle and is activated after addition of serum. VRK1 gene behaves as an early response to serum, and its expression parallels that of the oncogenes MYC and FOS. Read the rest of this entry »

    Comments Off on New features of the VRK kinases
  • The word “cancer” is terrifying to most of us because it carries with it images of doom. However, there is no one disease called “cancer” but rather a number of diseases that share a common feature: the growth of cells that have lost the ability to control the cell cycle. Some of these diseases are quite treatable, while others are much more difficult and are, in fact, life threatening and often terminal.

    The commonality of the diseases has to do with the cell cycle itself, shown below with several of the key control points indicated: Read the rest of this entry »

    Comments Off on Cancer as a Disease of the Cell Cycle