Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images9Procesos como el desarrollo embrionario, la angiogénesis, la cicatrización de heridas y la metástasis se basan en la migración celular, un complejo proceso regulado por múltiples rutas de señalización intracelular. Las integrinas y las GTPasas de bajo peso molecular de la familia Rho/Rac son algunos de los reguladores más importantes de este proceso. Read the rest of this entry »

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  • images69The interaction between genomic regulatory elements (cis) and transcription factors (trans) is one of the main avenues for modulation of the transcriptome, while it deregulated in pathological conditions such as cancer. In turn, the repetitive genomic elements (LTR and retrotransposons) represent 40% of the volume of the mammalian genome and their functionality is yet to be defined. In this study, researchers at the University of Extremadura identified a new murine retrotransposon B1 SINE family (named B1-X35S) present in the promoter region of more than 1300 genes. B1-X35S is characterized by binding sites for transcription factors AhR (XRE site) and SNAI2 separated by a conserved sequence of 35 nucleotides. Read the rest of this entry »

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  • images64Since the middle of last century was known that in vertebrates, meiosis and early embryonic divisions required polyadenylation and translational activation of maternal mRNA stored in the oocyte. However, it was not until the nineties when it began to elucidate the molecular mechanism of the expression of these mRNA, with the discovery of some of the major factors involved in the process. Read the rest of this entry »

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  • images63Failures in the replication of genetic material during cell division leads to the activation of the checkpoint (checkpoint) of replication, conserved in eukaryotes. When it detects replicative stress cellular responses are activated to preserve the integrity of the genome, including the stabilization of replication forks, the activation of a specific transcriptional program and the slowing of the cycle to prevent entry into mitosis in the absence of adequate replication genetics. The principal effector in Schizosaccharomyces pombe Cds1 kinase is homologous to mammalian Chk2, which plays an essential role in stabilizing replication forks under stress. This kinase regulates events in brackets recombinogénicos stops and coordinates the resumption of replication when stress ceases and cells undergo an adaptation process. Read the rest of this entry »

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  • new-regulation-for-a-particular-function-of-insulinInsulin is a paradigm of regulation and specific function. Essential anabolic hormone in the adult, seems to have a different role during embryonic development. A group from the Center for Biological Research, CSIC has been characterized step by step this new role. Insulin, as its precursor proinsulin and acting through insulin receptor hybrid with the growth factor insulin-like IGF-I, regulates the process of programmed cell death in the early stages of development of the nervous system stage where this process is, in turn, little studied. Read the rest of this entry »

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