Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images17Understanding the mechanisms of protein production, how and why they fold in a certain way, how they act and interact, and ultimately better understand how they work, is one of the most exciting challenges facing the biomedical sciences. In this sense, Biocomputing, with supercomputers as key tools is enabling many of the puzzles to reveal still open on these key players in the diversification of life functions of organisms. In recent years, scientists have discovered that protein function is determined by both its stable structure as the conformational changes occurring in terms of external stimuli. This is what has been called, in recent studies, molecular flexibility proteína.1, 2 Read the rest of this entry »

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  • images14The human genome sequence has been a breakthrough for modern biology, a milestone similar to the discovery of the structure of the DNA chain or by the assumption that each gene codes for a protein. Despite its importance, and our current view of biology, these data are static. So today we take into account many more elements to understand the process of differentiation and functional specialization of cells with the same genome. One approach is to look at the result of the expression of the genome, ie proteins that are synthesized from the information contained in DNA. This level of analysis gives us a dynamic view on how much of the genetic information is expressed in the cell at a given time. Furthermore, it is a higher level, that of functional protections: when there is a change in the environment, our genome remains unchanged, while our protease can be modified to preserve the physiological properties of cells .

    The proteins, once synthesized, are modified by the attachment of other molecules in a stable or unstable, which can radically alter the final biological activity of the protein. The post-transcriptional modification (RNA editing) and post translational (phosphorescent, constellation, adulation and cleavage, etc.) Allow for protein biological activity very different part of the same gene. This overview is attached to the modeling of phenomena of structural conformation of proteins and their multiple interactions at different levels, offer a global map of the molecular dynamics of proteins in the work discussed below.

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  • protein-characterizationAfter specific proteins are identified for further research, they are excised from the gel and treated with a succession of enzymes that cut amino acid chains into short polypeptides about 5-10 amino acids in length.

    The polypeptide fragments for each protein are then separated by capillary electrophoresis and analyzed using rapid-throughput mass spectrometry. At this point, we know the amino acid sequence of the polypeptide fragments, their mass, as well as post-translational modifications that occured such as glycosylation and phosphorylation. Read the rest of this entry »

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  • image199Understanding the control of cell division is one of the great challenges of biology, for its implications in the generation of multicellular organisms and in proliferative processes such as oncogenesis. The tool to achieve such knowledge used by the groups of the Andalusian Center for Developmental Biology, CSIC, Seville, and the Cancer Research Center of Salamanca signing this collaboration is the fission yeast Schizosaccharomyces pombe, which analyzes the mechanisms coordinate control various processes involved in cellular mitosis, and cytokinesis. Read the rest of this entry »

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