Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • resize2Questions about the origin and definition of life can be answered from different perspectives: thermodynamics, physiological, metabolic, biochemical or genetic. The latter focuses on the characterization of information flows and nucleic acids and proteins that carry. Efforts to consolidate these perspectives lead to a definition derived from the so-called cell theory, based on three basic elements: the presence of a semipermeable boundary (cell membrane), a unit of energy production and processing systems and management information (the proteome and the genome). These assumptions define minimum cellular organism as simple as possible. But we shall see, this is just theory. The plasticity of nature and the potential inherent in the evolution have led to bridge the world of living beings who are in a real interface, which meet some of these requirements, but lack other to survive and prosper independently. Read the rest of this entry »

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  • images14The human genome sequence has been a breakthrough for modern biology, a milestone similar to the discovery of the structure of the DNA chain or by the assumption that each gene codes for a protein. Despite its importance, and our current view of biology, these data are static. So today we take into account many more elements to understand the process of differentiation and functional specialization of cells with the same genome. One approach is to look at the result of the expression of the genome, ie proteins that are synthesized from the information contained in DNA. This level of analysis gives us a dynamic view on how much of the genetic information is expressed in the cell at a given time. Furthermore, it is a higher level, that of functional protections: when there is a change in the environment, our genome remains unchanged, while our protease can be modified to preserve the physiological properties of cells .

    The proteins, once synthesized, are modified by the attachment of other molecules in a stable or unstable, which can radically alter the final biological activity of the protein. The post-transcriptional modification (RNA editing) and post translational (phosphorescent, constellation, adulation and cleavage, etc.) Allow for protein biological activity very different part of the same gene. This overview is attached to the modeling of phenomena of structural conformation of proteins and their multiple interactions at different levels, offer a global map of the molecular dynamics of proteins in the work discussed below.

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  • images39The gene regulation of mRNA degradation mediated by elements rich in adenine and uracil bases (ARE) is important both in cellular and physiological proliferation in the immune response and cardiovascular tone.

    One of the ARE binding proteins is the KSRP (K homology Splicing Regulator-Protein) that recruits the exosome favoring different mRNA degradation. Read the rest of this entry »

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  • apoptotic-mechanisms-of-granzymes-in-ctl-lysisCytotoxic T lymphocytes (CTLs) eliminate virus-infected tumor cells or alloantigen through a lyric mechanism, which involves the secretion of a cytoplasmic granules containing cytotoxic proteins, perforin and granzymes, of which the two most important are granzyme A and granzyme B. Perforin interacts with cell membranes and allows the access of granzymes into the target cell, inducing cell death by apoptosis. Read the rest of this entry »

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