Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
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All processes of gene activity are accompanied by alterations in DNA helical tension. Consequently, the double helix twists on itself, or supercoiled to remain stable throughout its length. This tension may be very high during the processes of transcription and DNA replication, since the two strands, always linked in the double helix, are forced to separate, in part or total. Due to the enormous length and the large condensation of DNA molecules in chromosomes, the coil voltage can not dissipate spontaneously. Read the rest of this entry »
The processes of metastasis, associated with 90% of cancer deaths, are a series of chained steps where the primary tumor invades surrounding tissues and just spreading throughout the body. One of the first tissues to suffer metastasis are the lymph nodes surrounding the tumor. Manel Esteller’s group has recently published an article in PNAS conducted in the National Cancer Research Center (CNIO), explaining how tumor cells escape from their original location to the lymph nodes. Read the rest of this entry »
The Chain Reaction (PCR) is a laboratory technique that permits copying in vitro of specific DNA sequences and has revolutionized the field of molecular biology. Conceptually, the PCR is a simple technique is to heat the separation of the two strands of DNA to be amplified is, and a copy simultaneously from a point determined by an artificial DNA fragment called primer, through the action of an enzyme called DNA polymerase. The result is a doubling of the number of molecules of a particular sequence of DNA. This process is repeated a number of times or cycles, such as 30, and achieved an increase or exponential amplification of the number of copies of template DNA fragment. Read the rest of this entry »
Gubbins and his colleagues are interested in understanding the more diverse and complex phenomena that occur in materials whose pores are only a few times larger than those of the fluid being taken up. They are using the advanced computing resources of the Cornell Theory Center to conduct their research. The results of investigations into such phenomena could point to new ways to remove poisonous gases from the atmosphere and to purify oil and water. Read the rest of this entry »
Pollination is an essential process in all ecosystems and is regulated by many factors, the aspect presented flowers to insects is one of them. Recent research, conducted by a group of the University of Murcia, have shown that the petals of the flowers of Mirabilis jalapa emit a particular pattern of fluorescence and suggested that this could be a new signal involved in pollination.
The authors describe the presence in the petals of this species, two pigments, one betaxantin betacyanin yellow and violet. The betaxantin is a pigment that absorb blue light emits green fluorescence, while the betacyanin has the capacity to absorb the light emitted by the first. When the two molecules are close enough in that region there is no emission of light, since the fluorescence emitted by one is absorbed by the other, an effect that is known as the internal filter. Read the rest of this entry »
The viral maturation process involves, essentially, the incorporation of the genome to procures protein.
In this work, developed in the group of doctors JM Values and J.L. Ratchet has been analyzed by electron microscopy assisted by computational analysis, the structural differences between the bacteriophage T7 procures and mature head, the one containing the genome. Read the rest of this entry »