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- PROPERTIES OF DNA
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Aware of the importance of electrostatic and hydrophobic interactions in the formation of complexes that allow an efficient electron transfer between
molecules, such as the ferredoxin NADP + reeducates (FNR) and ferredoxin (Fd). The FNR catalyzes the transfer of electrons sequentially from two molecules of Fd to NADP + molecule in order to store energy in the form of reducing power NADPH.
We have seen that certain residues in the FNR are also critical for interaction with flavodoxin (Fled), redo protein binding of flaying mononucleotide, though,
so far, has not found any clue to her that waste may be associated with side
chains of FNR.
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To maintain genomic stability, mammalian cells require the action of five proteins encoded by paralogous genes to that of RAD51, a molecule involved in DNA repair, implying orquesrado operation of certain protective mechanisms.
In previous work on RAD51 protein, essential in homologous recombination, has established its relationship to repair mechanisms. Their action, in response to gene damage depends on BRCA2 (protein related to breast cancer) and a series of proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), known as the RAD51 paralogues. The paralogy, understood as a degree of specialization adopted by horizontally related genes, can deliver a complete answer to the questions raised in this paper. Read the rest of this entry »
The cover image of the international edition of the February 13 issue of the journal Angewandte Chemie German represents a new form of DNA helices formed by three researchers who have described CSIC, Institute of Biomedical Research of the PCB and the University of Birmingham, in a collaboration that has found a surprising structure almost by chance, while trying to test the effectiveness of a drug as a therapeutic agent against DNA targets. Read the rest of this entry »