Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
- The epigenetics of cancer, a recent view
- Structure of an enzyme and its in hibitor
- Rolling Circle Amplification Technology–Technical Details
- Human skin analysis
- Development and morphogenesis: potentialities from common patterns
- PROPERTIES OF DNA
- Induction therapy of autophagy and apoptosis in melanoma cells
- Cancer as a Disease of the Cell Cycle
- Tigar or how p53 controls glycolysis
- Molecular basis of interactions between integrin and plectina
- Parallel evolution of the venom of snakes and integrin
- RCAT™—Research Reagents
- Molecular link between aging and cancer
- The mitofusin 2 in mitochondrial energization
- Apoptotic mechanisms of granzymes in CTL lysis
In our earlier “A Fund” section opened with the analysis of a Spanish paper published in Nature (Ferris Marco et al., 2006). And we congratulabamos therefore it is still uncommon to see in that publication a study conducted entirely by Spanish investigators. It seems that our discussion had taken effect in the minds of so renowned editorial publication, and this month we have an equivalent opportunity to rejoice at the appearance of another article malignancy in Spanish on the British magazine par excellence. This time it’s a research on the regulation of a tumor suppressor locus. Read the rest of this entry »
Mammals are unable to synthesize metabolically various amino acids necessary for protein synthesis and should incorporate foods from the diet. These amino acids are called essential. Photosynthetic organisms can synthesize it. Has long been accepted that the metabolic pathways involved in the biosynthesis of amino acids in plants are identical to those in microorganisms. However, recent results indicate significant differences and a higher level of complexity due to the existence of multiple enzymes that are distributed in different subcellular compartments. Read the rest of this entry »
Professor of Biochemistry and Molecular Biology, University of Oviedo, Carlos Lopez Otín, is an internationally renowned scientist. In his lab have done outstanding work that opened the door to important research avenues for diseases like cancer, arthritis or many inherited diseases, some of them discovered by his team in the Asturian capital. Otín Lopez earned his doctorate at the Universidad Complutense de Madrid in 1984 and since 1987 is part of the Faculty of Medicine of Oviedo, where he heads a group of basic research in molecular biology. Read the rest of this entry »
The control of gene expression depends on the access of chromatin gene regulatory areas to the transcriptional machinery. The covalent modifications of histones as acetulaciones and methylation are key factors to regulate that access. Reading the information contained in these posttranslational modifications of histones depends on the function of effector proteins. Therefore, understanding the mechanisms of recognition of these effectors and how histone modification patterns result in complex patterns of expression is key to understanding the transcriptional process. Read the rest of this entry »
All the talk will focus on what conditions should apply to a laboratory of Molecular Biology, clinical type. While Molecular Biology covers various fields during the exhibition will emphasize that associated with nucleic acids: DNA and RNA.
After displaying a slide showing the spatial organization of the Molecular Biology Laboratory Diagnostics Ampligen will expose what were the reasons for such distribution, which are absolutely necessary instruments for each of the areas to function autonomously and independent. Read the rest of this entry »
Hybridization solution: The probe and target nucleic acid are in a liquid. The hybridization conditions must be in order. The rate of formation of the duplex under these conditions is high. The problem with this type of hybridization is the elimination of unreacted probe, using among other methods nuclease S1-precipitation with trichloroacetic or hybridization protection assay. Read the rest of this entry »
Few areas of molecular biology have not changed with the emergence of a number of techniques subsumed under the generic term for Genetic Engineering and interchangeably referred to as cloning, recombinant DNA or genetic manipulation. Before the development of Genetic Engineering was not possible to isolate a particular eukaryotic gene in sufficient quantities for study molecular or your product. Read the rest of this entry »
A lysine residue located at position 422 in the sequence 2 lysine transporter GLYT2, located in the plasma membrane of neurons, is essential for the transport of amino acid eurotransmitter functions. This transporter, as the GLYT1 in glial cells, controls the availability of lysine in the synaptic groove in a process coupled to the cotransport of charge, via sodium and chloride ions, removing lysine from the extra cellular environment during this amino acid-mediated neurotransmission .
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The bacterial conjugation, the main route for horizontal gene transfer to prokaryotes, is a quick way for the evolution of bacterial genomes leading to organisms with new ecological or pathogenic characteristics. The acquisition of antibiotic resistance by pathogens is related to the conjugal transfer of mobile genetic elements. The transfer of genes between kingdoms, from bacteria to plants and fungi, are special cases of conjugation and even in cell division and sporulation, there are similar mechanisms for transfer.