Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images22In our earlier “A Fund” section opened with the analysis of a Spanish paper published in Nature (Ferris Marco et al., 2006). And we congratulabamos therefore it is still uncommon to see in that publication a study conducted entirely by Spanish investigators. It seems that our discussion had taken effect in the minds of so renowned editorial publication, and this month we have an equivalent opportunity to rejoice at the appearance of another article malignancy in Spanish on the British magazine par excellence. This time it’s a research on the regulation of a tumor suppressor locus. Read the rest of this entry »

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  • images48The cells of any living being divided by two different mechanisms: through mitosis, which is the way in which cells are involved in normal cell growth in most living organisms, and through meiosis, the process by formed sex cells or germ.The meiotic cell cycle differs from the mitotic to have a phase called premeiotic DNA synthesis. This phase is characterized by high levels of recombination and two successive nuclear divisions. REM1 is a cyclin that is expressed only in meiosis in the fission yeast Schizosaccharomyces pombe. Read the rest of this entry »

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  • images47The research group on Oxidative Stress and Cell Cycle, which is co-leader Jose Ayte within the Department of Experimental Sciences and Health, Universitat Pompeu Fabra in Barcelona, is an enthusiastic lab whose main interest is the characterization of cellular responses to stress oxidative and cell cycle control as a model organism using the fission yeast Schizosaccharomyces pombe. The team uses cutting-edge methodological approaches in molecular biology, proteomics and imaging live cells, in addition to classical genetics. Read the rest of this entry »

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  • essential-phosphorylation-against-cellular-stressThe activation of stress protein kinases is essential for proper cellular adaptation to external stimuli. In the yeast Saccharomyces cerevisiae, an increase of extra cellular osmolarity activates the MAP kinase pathway of Hog1, which is derived from a complex adaptive response. Researchers at the Universitat Pompeu Fabric and Universitat International de Catalonia have characterized various aspects of the response, revealing that one of the protective mechanisms induced Hog1 arrests the cell cycle in G1 phase, through a twofold process that ends with inhibition of CDK (cyclin dependent kinase), a key enzyme that allows cell cycle progression. Read the rest of this entry »

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