Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images42Alzheimer’s disease (AD) and other neurodegenerative processes are characterized by a deregulation of intracellular levels of neuronal Ca 2 +. This alteration seems to carry an implicit cause-effect relationship to toxicity by the β-amyloid peptide and neuronal death, although the mechanisms involved are discussed. One of the systems with higher affinity for Ca 2 + is formed by the Ca 2 +-ATPase. In a study conducted by Ana M. Mata, Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, have investigated the functional dependence of Ca 2 + ATPase of plasma membranes and intracellular in human brains affected by AD. Read the rest of this entry »

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  • genetic-disorderIf an organism carries a harmful genetic mutation, it can still survive and sometimes even function normally if something in the organism’s environment can compensate for the genetic defect. In this situation, the organism may not appear mutant at all (in other words, though its genotype is mutant, its phenotype is normal – click here for more definitions). Sometimes missing substances normally made by the product of the mutant gene can be provided, or substances normally removed by the product of the mutant gene can be limited in the diet. Read the rest of this entry »

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  • fly_antenna1Scientists discovered the existance of genes that determine body plan by analyzing bizarre aberrations in body form that resulted from mutations in fruit flies. For example, Ed Lewis and his colleagues observed fruit flies with legs growing from the head in place of antennae (for real!). They found that a single mutation in a gene could make this happen. Read the rest of this entry »

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  • inheritenceHow are genes passed from parent to child? Genes are composed of a chemical called DNA. The many, many genes needed for all the biological functions of an organism are found linked together in the cell on extremely long pieces of DNA, called chromosomes. Each human cell (except sperm and egg cells) has two copies of each chromosome, one from the mother and one from the father. Read the rest of this entry »

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  • There is a worldwide epidemic of childhood obesity in the last fifteen years. What are the roles of heredity and environment? This is what British researchers wanted to determine by looking at 5092paires twins (1813 and 3279 true false) aged 8 to 11 years at the time of the study. If the influence of heredity is dominant, mass index (BMI) of identical twins must evolve identically, contrary to the BMI of twins. Read the rest of this entry »

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  • pharmacogeneticsThis new Incyte program will focus on identifying the role of genetic diversity in disease and drug response by developing technologies and programs for the pharmaceutical industry in polymorphism discovery, genotyping and pharmacogenetics.

    The Future of Drug Development

    Understanding the key genetic differences between individuals will enable pharmaceutical researchers to create better therapeutics. Improved therapeutics can reach new levels by being able to differentiate between individuals according their predisposition to disease processes or susceptibility to adverse effects of medications. Read the rest of this entry »

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  • primer-on-molecular-genetics1Title: Primer on Molecular Genetics
    Creator: Human Genome Management Information System, U.S. Department of Energy (DOE), Oak Ridge National Laboratory
    Provider: William H.Welch Medical Library, The Johns Hopkins University

    Description: The Primer on Molecular Genetics is an introduction to the science behind the human genome project and was prepared for the Department of Energy’s (DOE) Human Genome Program Report for 1991-92 . This document contains information on the Biology of DNA, techniques for Sequencing and Mapping Genes, and Genome Informatics. Figures are included. It is currently under revision. There are two versions available, an Adobe Acrobat version (which allows users to print originals) and a html version.

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