Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
- The epigenetics of cancer, a recent view
- Structure of an enzyme and its in hibitor
- Rolling Circle Amplification Technology–Technical Details
- Human skin analysis
- Development and morphogenesis: potentialities from common patterns
- PROPERTIES OF DNA
- Induction therapy of autophagy and apoptosis in melanoma cells
- Cancer as a Disease of the Cell Cycle
- Tigar or how p53 controls glycolysis
- Molecular basis of interactions between integrin and plectina
- Parallel evolution of the venom of snakes and integrin
- RCAT™—Research Reagents
- Molecular link between aging and cancer
- The mitofusin 2 in mitochondrial energization
- Apoptotic mechanisms of granzymes in CTL lysis
A rare disease characterized by premature aging is modeled after a group of Spanish scientists to better understand the relationship between cancer, genes and aging. This is Werner syndrome, an inherited disorder characterized by premature aging of the individual, genomic instability and an increased incidence of tumors. The study was conducted jointly by researchers at the Hospital Clinic of Barcelona, Biomedical Research Center of Navarre, the National Institute on Aging U.S., and the group of Manel Esteller of the CNIO. Read the rest of this entry »
It is no novelty influence the monumental work of Joan Massagué and his team from the Memorial Sloan-Kettering Cancer Center in New York, where he is director of Biology and Cancer Genetics. Massagué, awarded in 2004 with the Prince of Asturias Award for Technical and Scientific Research, has for two decades in the United States to develop his career and achieved great success in research. Massagué is also a researcher at the prestigious Howard Hughes Institute, deputy director of the Institute of Biomedical Research and a member of the National Academy of Sciences of the United States and the European Molecular Biology Organization .
Joan Massagué has spent most of his research in the field of cell division and processes associated with tumor metastasis, striving to unite the work of basic research and clinical, laboratory and patient. Massagué and his many disciples, some of them researchers and practicing in Spain, have consolidated a few years deciphering some of the genes involved in the spread of tumors from one organ to another.
His numerous works, widely cited in scientific literature, highlights the role of some genes in the development of new tumors and in particular the decisive intervention of others, independently or in conjunction with the above-in the spread of cancer cells to other organs. Among these studies, the most recent open the possibility of new drug therapies designed based on the patient’s genetic profile, conferring specificity tremendously important to save the diversity of causes involved in the occurrence of a given tumor.
Colorectal cancer is a leading cause of cancer death worldwide. Most of these tumors as benign lesions, but a small proportion may progress to malignant stages to accumulate genetic alterations in oncogenes and tumor suppressor genes. It is estimated that between 30 and 50% of people over age 60 may develop these benign adenomas. Colorectal cancer is in first position of the record of most common cancers in Spain and causes more than half a million deaths each year worldwide. The team’s work Batlle on tumor initiation and progression of it, from the early stages until the formation of aggressive tumors, has discovered and examined cellular and animal experimental models that mimic this devastating disease, with the ultimate goal of power design new diagnostic and therapeutic tools. Read the rest of this entry »
Many studies in the yeast Saccharomyces transcriptomic in analyzing the gene expression program in a variety of conditions. Most if not all the cited studies analyzed only the different levels of mRNA by conventional genomic techniques. Indeed, in many cases implicitly assumes that the levels of each mRNA are a direct consequence of the action of one or several transcriptional regulators. This does not take into account that mRNA levels depend both on its rate of synthesis and the degradation. This study, ‘paper of the week “in the journal J. Chem, is a collaboration between two groups at the universities of Lleida and Valencia, under the responsibility of Henry Smith and Jose Enrique Pérez-Ortín, respectively. Read the rest of this entry »
This paper identifies a group of genes specifically involved in breast cancer metastasis to lung, a finding that has been made possible by combining studies of selected cell lines in vivo, transcriptomics, functional verification and subsequent clinical validation. In many cases, the genes identified had not previously been linked to metastatic processes. Read the rest of this entry »