Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • anti-hsp90-in-multiple-sclerosis1

    Researchers at the Hospital Ramon y Cajal de Madrid are antibodies against the protein Hsp90 in patients with multiple sclerosis (MS). This central nervous system disease characterized by chronic demyelination of axons and progressive loss of neuronal function, whose cause is yet determined, although recent studies indicated that it is not only from destruction of myelin or oligodendrocytes that produce it, but it is the lack of remyelination and production of new oligodendrocytes that the chronic.
    In this work the authors have linked this alteration in the expression remyelination in the cell surface of oligodendrocyte precursor cells (OPC), Hsp90 protein-beta (or HSP84). Read the rest of this entry »

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  • 41Cancer is a genetic disease and epigenetics. The first thing is have ample evidence for years. Of the latter being generated every day more conclusive evidence. Demonstrate it has cost, despite the intense research carried out in this field and know the common feature in cancer cells provides the inactivation of tumor suppressor genes by mechanisms such as changes in the patterns of methylation of histones and DNA. Read the rest of this entry »

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  • images27The hemooxigenasa 1 as a mediator in The hemooxigenasa 1 (HO1) is an inducible enzyme involved in home metabolism and is expressed in lesions of patients affected by Kaposi’s sarcoma. Apparently, its expression in endothelial cells is regulated by the herpes virus associated with Kaposi’s sarcoma (KSHV), although the exact mechanisms that induce the expression of HO1 by this virus are still unknown. A fully signed work by researchers at the Autonomous University of Madrid and published in the latest April issue of The Journal of Biological Chemistry has been proposed to investigate the possible role of G protein-coupled receptor (vGPCR)-product of one gene herpes virus linked to the development of Kaposi’s sarcoma-in activating the expression of HO1. Read the rest of this entry »

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