Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • 2Embryonic development and morphogenesis of individual organs are common schemes based processes. In them, groups of undifferentiated cells, they initiate a series of complex interactions with internal and external signals, in order to establish patterns that direct cells to their subsequent proliferation, differentiation, coordinated morphological change and migration. This seemingly elementary, requires the integration of a series of activations and changes in the expression levels of a few basic genes. Two mechanisms are paramount in this general scheme: the proper control of temporal and spatial activation patterns of cell signaling, and the union of these patterns with cellular effectors that activate cellular responses in terms of gene activity or cell morphology. Read the rest of this entry »

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  • resize7Researchers Differentiation and Cancer Programme of the Centre for Genomic Regulation in Barcelona (CRG) have shown, in an article that took the cover of a recent issue of Cancer Cell, the connections between DNA methylation mechanisms and the complex Polycomb protein, both involvedyear in Nature that the two mechanisms mentioned above could be interconnected with each other biochemically regulate genes together. Now what we have done is to check in tumor cells of patients with acute promyelocytic leukemia. The work has shown that two mechanisms are not only interconnected, but one reinforces the other and, moreover, one needs the other. This is an important contribution for future drug therapy, since it assumes that if you can correct the activity of one of the two mechanisms regulated erroneously reverse the actions of another. Read the rest of this entry »

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  • images85AKR1B10 is a aldocetoreductasa (AKR) especially interesting for two reasons: it is overexpressed in lung cancer and precancerous lesions of smokers and becomes very efficient, the retinal to retinol, retinal reductase being the most active among AKR. Researchers from the Universitat Autònoma de Barcelona, IBMB, IRB Barcelona, and Universidade De Vigo CRQT propose that both features could be related through the alteration of the signaling pathway of retinoic acid. This compound, synthesized by successive oxidation of retinol (vitamin A) to retinal, and thence to acid molecule is a potent regulator of differentiation celular.Una AKR1B10 high expression, potentially induced by snuff, would result in a significant decrease retinal cell levels and, consequently, retinoic acid, which could lead to lack of differentiation, and induce cancer cell proliferation and . Read the rest of this entry »

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  • images55Understanding how cells organize and coordinate to form the tissues and organs in living organisms (morphogenesis) is a basic question in developmental biology. The morphogenesis requires a number of cellular processes that occur in a coordinated way in small groups of cells, including proliferation, migration, differentiation, growth, and reposicionamento rearrangement of cells within the tissue. The end result of all these processes is to form a body-dimensional structure-from the initial flat structure which are the first cells of the embryo. Read the rest of this entry »

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  • images8The Ras superfamily of GTPases regulate important cellular processes like cell proliferation, differentiation and cell survival, mutations involving the development of cancer. In cancer, apart from the Ras proteins (H-Ras, N-Ras and K-Ras) are also implicated other proteins such as TC21, which shares most of the Ras effectors. TC21 protein may be farnesyl and geranyl, while Ras farnesyl just are. Read the rest of this entry »

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