Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • 197-32Research in the past eight years has driven the classical idea that nuclear processes occurring from transcriptional activation to the mature mRNA out of the nucleus were independent events. The work of many groups has contributed significantly to turning this vision of gene expression, and currently accepted model of coupled processes that ensure the proper output for translation of mRNA in the cytoplasm. Read the rest of this entry »

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  • 197-31The export of messenger RNA from nucleus to cytoplasm is an essential process in eukaryotic cells. Sus1 protein plays a significant role in the coupling between the initiation of transcription and mRNA export. Sus1 is a small protein (11kDa of only), conserved in eukaryotes that physically interacts with two stable multiprotein complex. Sus1 binds to the transcription activator complex SAGA and the complex formed by TREX2 binding proteins nuclear pore. In previous studies the group of Rodriguez-Navarro, Sus1 identified that is part of a submodule of SAGA, comprising Sus1-Ubp8-Sgf1, and responsible for deubicuitinación of histone H2B. Read the rest of this entry »

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  • 197-3The Prince Felipe Research Center in Valencia counts among its researchers with a young and active team led by Susana Rodriguez-Navarro, dedicated to understanding how messenger RNAs are produced and exported from the nucleus to the cytoplasm, a process that requires understanding a complex processing the primary transcript.

    Rodriguez-Navarro holds a doctorate from the University of Valencia, and after defending his doctoral thesis, conducted a four-year postdoctoral fellowship as a Marie Curie Fellow at the Zentrum Biochemie Universitat Heidelberg, Germany, in the laboratory of Dr. Ed Hurt. Read the rest of this entry »

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