Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • 5The transition between each of the phases of the cell cycle is controlled by phosphorylation processes carried out by enzymes known as cyclin dependent kinase (CDK). In mammalian cells, the enzyme bound to CDK2 cyclin A acts as the main promoter of the transition from G1 to S phase cell cycle progression and S phase, when DNA replication. Thus, the cyclin A-CDK2 complex binds to a large number of regulatory proteins at different times during cell cycle progression. Read the rest of this entry »

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  • images61The ability of locomotion of cells to certain stimuli requires deep and dynamic changes in cell morphology and cell adhesion. Many of these attractive stimuli in the cell membrane activate G protein-coupled receptor (GPCR), which emit signals that modify the one hand, the actin cytoskeleton, allowing the extension of the cell body in the direction of the stimulus source and shrinkage at the opposite end, and secondly, a decrease in the stability of the anchoring structures of the cell to the medium. Proper regulation of the two families of receptors, GPCRs and integrins ensures controlled migration. By contrast, poor regulation and integration associated pathologic migration due to cancer, chronic inflammation or vascular changes. Read the rest of this entry »

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