Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • str49Sirtuins (SIRT), protein family of histone deacetylases (HDAC) are involved in processes such as longevity, cancer, gene regulation, energy homeostasis and apoptosis.Inhibitors of sirtuins have antitumor properties, but so far no known inhibitor, such small molecule that is capable of discriminating between different members of the family of sirtuins.

    The study, conducted by the groups of Dr. Fraga (Cancer Epigenetics Laboratory of National Cancer Research Center, CNIO) and Dr. Esteller (Program for Epigenetics and Cancer Biology at the Catalan Institute of Oncology, ICO), describes the design, synthesis and biological activity of Salerno, a new and potent inhibitor in vitro of sirtuins SIRT1 and SIRT2. Read the rest of this entry »

    Comments Off on The Salerno: new selective inhibitor of sirtuins with proapoptotic activity
  • images31If neurons use glucose for oxidative stress defense, then where do get the energy? Astrocytes, close neighboring neurons and cerebral microvessels, metabolize glucose very quickly that catch the blood. To this end, dependent protein kinase 5′-AMP (AMPK) is responsible to keep active Pfkfb3 providing a robust glycolytic activity. Moreover, removal of glutamate from the synaptic cleft, astrocytes engaged to enable neurotransmission, is coupled, through a bioenergetic mechanism-a activation of glycolysis. Read the rest of this entry »

    Comments Off on Bioenergetic coupling astrocyte neuron: an example of collaboration
  • images27The gene TARBP2 (TAR-RNA binding protein 2) is key to the production machinery of microRNA. These microRNAs are short strands of ribonucleic acid that regulate the intensity of the activity of other genes activated and deactivated, and active oncosupresora has been demonstrated in the past. In this study, conducted by a group of scientists from Finland, Portugal, USA and Spain, led by Manel Esteller, who led the group in the Cancer Epigenetics CNIO in Madrid and currently leads the Epigenetics of IDIBELL in Barcelona, have examined a number of cell lines of colorectal cancer, Read the rest of this entry »

    Comments Off on Loss of functionality of the production of microRNAs in tumorigenesis
  • oncogenom

    oncogenom-11To most patients with cancer—and even to the physicians caring for them—the word “genomics” has little or no meaning. Many are vaguely aware that genomics has something to do with genes and may somehow relate to a genetic risk for cancer within families. However, when told that genomics entails an attempt to “fingerprint” their cancer, they immediately grasp the basic concept. Patients and physicians know that hardly a month passes without the popular press announcing a major breakthrough in our understanding of cancer. Read the rest of this entry »

    Comments Off on Oncogenomics: Problems and promise
  • cdk-data-to-rule-out-the-fight-against-cancerA cyclin-dependent kinases Cdk4 and Cdk6 are attributed a crucial role in the initiation of cell cycle in response to mitogenic stimuli. They are, therefore, be targets toward which the biomedical sciences and pharmaceutical industry directed its efforts to intervene in the trigger mechanisms of cancer (some ant tumor drugs in Phase II clinical research, which has placed considerable trust, act inhibiting its activity). Read the rest of this entry »

    Comments Off on Cdk data to rule out the fight against cancer
  • stem28lf1_196556gm-a4This paper identifies a group of genes specifically involved in breast cancer metastasis to lung, a finding that has been made possible by combining studies of selected cell lines in vivo, transcriptomics, functional verification and subsequent clinical validation. In many cases, the genes identified had not previously been linked to metastatic processes. Read the rest of this entry »

    Comments Off on Identified the genes that direct the breast cancer metastasis to lung
  • stem28lf1_196556gm-aThe loss of cell polarity and cancer are two processes are related, although there is no direct evidence to explain this correlation. In stem cells, loss of cell polarity and consequently, the alteration of the division process could produce cells unable to respond to the mechanisms controlling the proliferation and lead to cancer cells. Research by Emmanuel Caussinus and Cayetano Gonzalez has raised two related questions: if the stem cells can become cancerous cells and if this process may be related to loss of polarity.

    To answer these questions have been developed in Drosophila melanogaster larval neuroblasts with mutations in genes that control asymmetric cell division (raps, look, numb or pros) and have observed their proliferative capacity after transplanting in the abdomen of adult flies. Read the rest of this entry »

    Comments Off on Stem cells can cause cancer
  • 61

    The infectivity of a virus is determined by its ability to
    avoid the whole machinery of the host cell defense presented. Vaccinia virus
    (orthopoxvirus family of which belongs to the virus which causes smallpox)
    exhibits a surprising: it is able to induce motility of cells infected, as
    evidenced by work done in the Motility Laboratory Cellular Cancer Research in
    London. The first author of an article published in Science, Ferran Valderrama,
    is a Spanish left the ranks of the Institute of Biomedical Research August Pi I
    Sunyer, University of Barcelona and is currently studying in the English
    capital, the cellular mechanisms involved in cancer . Read the rest of this entry »

    Comments Off on Vaccinia set up cells
  • 51The genetic model of cancer has led research in this field for decades, until Feinberg and Vogelstein (Johns Hopkins) described in 1983 an extensive loss of DNA methylation in tumor cells. With the results came the first evidence that epigenetic changes, heritable but outside the sequence, could make the cancer. The manifest skepticism that greeted the idea was in part due to the slow pace of progress in this field over the next fifteen years. Read the rest of this entry »

    Comments Off on The epigenetics of cancer, a recent view
  • 21There are items that make a difference, appearing one at the right time, involving a breakthrough or provide any major surprises. It must then stop to reflect, to contextualize and deepen. With this in mind we opened section. As we have been doing regularly, we discuss the reference and appreciate your interest, but delve into the subject by giving it a context and a time that, in this case, it is particularly recent. Read the rest of this entry »

    Comments Off on Evidence of epigenetic cancer causes