Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images23Cancer, such as biological process that goes beyond the laws of development and cellular growth, requires relocation process and investigate molecular mechanisms that lead to uncontrolled cell division, genomic instability and tumor development. The identification of these new patterns of growth and development can be very important to understand and combat processes tumorogénesis.1 It appears from research such as referenced here, the Cdc6 and other cellular components are joined, forming complexes prerreplicativos before initiated DNA duplication. Read the rest of this entry »

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  • 3A rare disease characterized by premature aging is modeled after a group of Spanish scientists to better understand the relationship between cancer, genes and aging. This is Werner syndrome, an inherited disorder characterized by premature aging of the individual, genomic instability and an increased incidence of tumors. The study was conducted jointly by researchers at the Hospital Clinic of Barcelona, Biomedical Research Center of Navarre, the National Institute on Aging U.S., and the group of Manel Esteller of the CNIO. Read the rest of this entry »

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  • resize1Epigenetic modifications of chromatin and telomeres have an important effect in regulating how and when our genes are expressed. Previous studies have shown that telomere shortening occurs in pathological situations such as cancer and the aging process. However, until now little was known about the overall impact of these defects and what their mechanisms of action. Read the rest of this entry »

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  • resize7Researchers Differentiation and Cancer Programme of the Centre for Genomic Regulation in Barcelona (CRG) have shown, in an article that took the cover of a recent issue of Cancer Cell, the connections between DNA methylation mechanisms and the complex Polycomb protein, both involvedyear in Nature that the two mechanisms mentioned above could be interconnected with each other biochemically regulate genes together. Now what we have done is to check in tumor cells of patients with acute promyelocytic leukemia. The work has shown that two mechanisms are not only interconnected, but one reinforces the other and, moreover, one needs the other. This is an important contribution for future drug therapy, since it assumes that if you can correct the activity of one of the two mechanisms regulated erroneously reverse the actions of another. Read the rest of this entry »

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  • images77Given the endless accumulation of complete genomes of a remarkable number of organisms, one of the immediate objectives of the post-genomic era is the functional description of all the genes that make up a genome. To this end, considerable effort has focused on experimental design methods with high analytical skills. Among them, induction of variation in the expression of cDNA libraries, which are tested in cell cultures. Along with this approach, the development of robotic systems provides massive data analysis and a multitude of variables taken together . Read the rest of this entry »

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  • images76AKR1B10 is a aldocetoreductasa (AKR) especially interesting for two reasons: it is overexpressed in lung cancer and precancerous lesions of smokers and becomes very efficient, the retinal to retinol, retinal reductase being the most active among AKR. Researchers from the Universitat Autònoma de Barcelona, IBMB, IRB Barcelona, and Universidade de Vigo CRQT propose that both features could be related through the alteration of the signaling pathway of retinoic acid. This compound, synthesized by successive oxidation of retinol (vitamin A) to retinal, and thence to acid molecule is a potent regulator of cell differentiation. Read the rest of this entry »

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  • images72

    Research in the field of molecular processes of aging in the
    last decade can be described as enormous, with many surprises that explain many
    basic biological processes of multicellular organisms. Blasco and her team make
    much of the progress occurring in this area of research. The concepts with which
    they work (cancer, aging, stem cells, telomere length and amount of telomerase)
    are woven together to shed light on the possible link between stem cells in
    cancer development and aging. Read the rest of this entry »

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  • images61The ability of locomotion of cells to certain stimuli requires deep and dynamic changes in cell morphology and cell adhesion. Many of these attractive stimuli in the cell membrane activate G protein-coupled receptor (GPCR), which emit signals that modify the one hand, the actin cytoskeleton, allowing the extension of the cell body in the direction of the stimulus source and shrinkage at the opposite end, and secondly, a decrease in the stability of the anchoring structures of the cell to the medium. Proper regulation of the two families of receptors, GPCRs and integrins ensures controlled migration. By contrast, poor regulation and integration associated pathologic migration due to cancer, chronic inflammation or vascular changes. Read the rest of this entry »

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  • images53The processes of metastasis, associated with 90% of cancer deaths, are a series of chained steps where the primary tumor invades surrounding tissues and just spreading throughout the body. One of the first tissues to suffer metastasis are the lymph nodes surrounding the tumor. Manel Esteller’s group has recently published an article in PNAS conducted in the National Cancer Research Center (CNIO), explaining how tumor cells escape from their original location to the lymph nodes. Read the rest of this entry »

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  • images41One of the tenets associated with cancer advocates that the inactivation of oncogenes leads to remission of the tumors, implying that oncogenes would be the real Achilles heel of cancer. This model has kept the oncogenes as a therapeutic target clear and agreed with the certainty that in human cancer all cancer cells, irrespective of the existing cellular heterogeneity in the tumor, carry the same genetic lesions Oncogenetics home. This view may now be questioned from a study on the effect of BCR-ABL oncogene in the development of cancer in an animal model of oncogene expression restricted to stem cells. Read the rest of this entry »

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