Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images79Three years ago, Eduard Batlle is ICREA research professor of the Generalitat de Catalunya and the principal investigator and coordinator of the Translational Oncology Program and the Institute of Applied biomedical research in Barcelona (IRB Barcelona). It has a complete history that includes extended periods of research in leading laboratories in oncology: completed his doctoral thesis at the Municipal Institute of Medical Research (IMIM) in 1999, spent nearly two years of postdoctoral researcher in the group in Germany and Miguel Beato four more in the Netherlands Institute for Developmental Biology . Read the rest of this entry »

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  • images66VRK proteins are a group of serine-threonine kinases involved in the regulation of p53 and other transcription factors involved in cellular stress responses. Most recently, Pedro Lazo’s laboratory at the Cancer Research Center of Salamanca has identified new aspects of the biology of two members of the family. The VRK1 kinase is required to carry out the cell cycle. VRK1 gene expression when standing stop the cycle and is activated after addition of serum. VRK1 gene behaves as an early response to serum, and its expression parallels that of the oncogenes MYC and FOS. Read the rest of this entry »

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  • images57Understanding the biology of aging and therapeutic approach to pathologies associated with its development are facilitated by the study of syndromes of accelerated aging or progeria. These syndromes are characterized by early onset of physiological changes normally associated with old age.Progeroid syndromes, Werner’s syndrome or progeria of the adult, are caused by defects in various systems involved in maintaining the integrity of genetic material. By contrast, the progeroid laminopatías are caused by defects in components of the nuclear envelope. Read the rest of this entry »

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  • images54Transcription is a process in eukaryotic cells is coupled to mRNA processing and transport. In recent years, we know that the transcription of at least a number of genes occurs at the nuclear periphery near the nuclear pore. In yeast ASaccharomyces cerevisiae proteins Thp1, Sac3 and Cdc31 form a complex (THSC), associated with nuclear pore affecting the process of transcription and RNA transport. This complex is also present Sus1, a protein identified as a component of the SAGA complex, involved in transcription initiation. Read the rest of this entry »

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  • images46Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG triplet expansion, enabling long polyglutamine sequence in the huntingtin protein. The disease appears in about 40 years and presents with involuntary movements, rigidity and personality disorders and leads to death after 15-20 years of suffering. There is no known pathogenic mechanism or treatment for HD. A key advance in this study was that an American group reported that inhibitors of ATP synthesis reduced neuronal death in models of HD in Drosophila and C. elegans (somewhat unexpected because an inhibition of energy metabolism had been described in patients and mice). Simultaneously, a Korean group found that extracellular ATP induces neuronal cell death by activation of P2X7 receptor, an ion channel permeable to Ca2 +, which modulates neurotransmitter release from the terminal presynaptic neurons and the release of cytokines in microglia. Read the rest of this entry »

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  • images42Alzheimer’s disease (AD) and other neurodegenerative processes are characterized by a deregulation of intracellular levels of neuronal Ca 2 +. This alteration seems to carry an implicit cause-effect relationship to toxicity by the β-amyloid peptide and neuronal death, although the mechanisms involved are discussed. One of the systems with higher affinity for Ca 2 + is formed by the Ca 2 +-ATPase. In a study conducted by Ana M. Mata, Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, have investigated the functional dependence of Ca 2 + ATPase of plasma membranes and intracellular in human brains affected by AD. Read the rest of this entry »

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  • images26The cell cycle progression is governed by a family of kinases (cdk: cyclin dependent kinases) whose activities are regulated by binding to regulatory subunits called cyclins. During the cell cycle and activate form specific pairs of cdk and cyclins. The pair CDK1 with cyclins A and B governs the transition G 2 / M. During the cell cycle cdk levels remain relatively constant and the cyclins fluctuate, thus activating specific cdk. Read the rest of this entry »

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  • a-therapeutic-target-cautionsMost sporadic colorectal cancers are initiated by activating mutations in the route Want (wingless type), whose products are implicated Eph receptors (Ephraim’s) and its ligands.A study on the development of colorectal cancer sample, for the first time that the activity of Eph receptors (responsible for controlling the structure of intestinal epithelium through repulsive interactions with their legends) cancels the progression of benign to malignant tumors. Read the rest of this entry »

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  • hammerheads-natural-more-efficient-than-their-artificial-derivatives1The hammerhead Ribosome natural, found in some various (small RNA of 250-400 nucleotides able to replicate and cause disease in certain plants), catalyze cis cutting their own oligomeric intermediates generated during replication by rolling circle mechanism. The hammerhead Ribosome, thanks to its structural simplicity, have been manipulated in this study to act in trans as restraining ribonucleases specific RNA, assuming that the similar catalytic behavior in this context is artificial. Read the rest of this entry »

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  • image199Understanding the control of cell division is one of the great challenges of biology, for its implications in the generation of multicellular organisms and in proliferative processes such as oncogenesis. The tool to achieve such knowledge used by the groups of the Andalusian Center for Developmental Biology, CSIC, Seville, and the Cancer Research Center of Salamanca signing this collaboration is the fission yeast Schizosaccharomyces pombe, which analyzes the mechanisms coordinate control various processes involved in cellular mitosis, and cytokinesis. Read the rest of this entry »

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