Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • 1We had not yet discussed in this section an article that brings up the inherent complexity of the phenomena of embryonic development. By definition, these processes and the formation of organs in many different and specialized cell groups involve the establishment of mechanisms from the linearity of DNA are able to construct a complex three dimensional arrangement in space and time.

    Such work represents a milestone in understanding basic biological processes, in many cases shared by the vast majority of living beings, and thus are the true touchstones in the evolution of complex multicellular organisms. Read the rest of this entry »

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  • images43In the laboratory of Fernando Rodriguez Pascual, Researcher, Center for Biological Research of the CSIC, are very interested in studying mechanisms regulating gene expression vasoconstrictor peptide endothelin-1 (ET-1) at both transcriptional and posttranscriptional . In a previous work, the group had reported that certain elements rich in adenine and uridine (AU-rich elements or ARE) present in the 3′-untranslated region (3′-UTR) of this gene contribute to the destabilization of mRNA.
    In the paper published in Molecular and Cellular Biology are proposed to analyze the factors and signaling pathways involved in this process of destabilization. The results have identified the glycolytic enzyme 3-glyceraldehyde phosphate dehydrogenase (GAPDH) as the major protein able to interact with ARE elements in the 3′-UTR of the gene for ET-1. The binding of GAPDH to these elements promotes the rapid degradation of mRNA. The study shows that GAPDH acts as a key sensor of oxidative stress. After a redox stimulus, during which the ratio reduced glutathione / oxidized glutathione decreases GAPDH key cysteine reacts with glutathione to form a mixed disulfide in a process called S-tiolación. Read the rest of this entry »

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  • flyAn online atlas and database of the Drosophilia Nervous System. Implementation of the pilot version of Flybrain, from the University of Arizona, supported by an SGR Grant from the National Science Foundation and a postgraduate studentship to Douglas Armstrong from the UK Biotechnology and Biological Sciences Research Council.

    A database on Drosophila brain and neural mutants developed by Prof. Karl Fischbach at the University of Freiburg, Germany. Current funds supporting the Flybrain database are from the US National Science Foundation  and a grant from the Deutsche Forschungsgemeinschaft

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