Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • ipla2In the Faculty of Medicine of the University of Valladolid, the group of eicosanoids studied the role of iPLA2 (phospholipase A2 calcioindependiente) in group VI in the process of incorporation and release of arachidonic acid from phospholipids and, ultimately, in the apoptosis. The PLA2 family is involved in the hydrolysis of arachidonic acid (AA) from phospholipids (PL). The iPLA2 involved in the incorporation of AA in the PL, ensuring the availability of intermediate acceptors. It is worth noting the role of these reactions in the cell life, as in resting cells prevail incorporation of arachidonic pathways on release, while cells stimulated the dominant reaction is the deacylation. Read the rest of this entry »

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  • images28Eicosanoids, proinflammatory compounds with high activity, including prostaglandins, leukotrienes, lipoxins, and in general all oxygenated metabolites of arachidonic acid. In cells, the polyunsaturated fatty acid is usually found esterified to membrane phospholipids. To join the synthesis of eicosanoids release is needed, what is responsible for a group of phospholipases. One of these key biosynthetic process involved in inflammation, cytosolic phospholipase (cPLA2α), which generates free arachidonic acid from membrane phospholipids. In fact, participating in the first stage regulator in the cascade of eicosanoid synthesis. Read the rest of this entry »

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