Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • str49Sirtuins (SIRT), protein family of histone deacetylases (HDAC) are involved in processes such as longevity, cancer, gene regulation, energy homeostasis and apoptosis.Inhibitors of sirtuins have antitumor properties, but so far no known inhibitor, such small molecule that is capable of discriminating between different members of the family of sirtuins.

    The study, conducted by the groups of Dr. Fraga (Cancer Epigenetics Laboratory of National Cancer Research Center, CNIO) and Dr. Esteller (Program for Epigenetics and Cancer Biology at the Catalan Institute of Oncology, ICO), describes the design, synthesis and biological activity of Salerno, a new and potent inhibitor in vitro of sirtuins SIRT1 and SIRT2. Read the rest of this entry »

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  • images28The mitochondrial protein BCL-2 family are critical in apoptosis. They are structurally related and can be classified as a functional and structural. Can be subdivided into multidomain proapoptotic proteins (such as BAX and BAK), multidomain antiapoptotic proteins (such as BCL-2), and BH3-only proteins (such as BID or BIM). All these lead to the regulated permeability of the mitochondrial outer membrane with release of cytochrome c and activation of effector caspases. They may also have other functions in other subcellular compartments. Read the rest of this entry »

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