Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • dis12cminGubbins and his colleagues are interested in understanding the more diverse and complex phenomena that occur in materials whose pores are only a few times larger than those of the fluid being taken up. They are using the advanced computing resources of the Cornell Theory Center to conduct their research. The results of investigations into such phenomena could point to new ways to remove poisonous gases from the atmosphere and to purify oil and water. Read the rest of this entry »

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  • RCAT™ is the ideal amplification method for biochips. No other practical amplification method can recognize, amplify and detect target molecules directly on a solid surface. Currently, gene arrays place spots or “elements” in a high-density matrix on slides. Each spot contributes a single piece of genetic information to the analysis. RCAT, from a single element in such an array, can obtain information on multiple analytes simultaneously, exponentially increasing the level of information available. Since RCAT can amplify and detect signal from a solid-phase target simultaneously, it provides the only means for a homogeneous biochip assay.

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  • Gene-Based Diagnostics Through RCAT™—Fast and Accurate
    Gene-based diagnostic tests are the fastest growing segment of the in vitro diagnostic market. They use the tools of molecular biology to identify nucleotide substitutions, deletions, or insertions in genes of medical interest. These tests provide several advantages over immunodiagnostic tests. For example, an immunodiagnostic HIV test, the current industry standard, detects the presence of HIV antibodies in blood. A person’s immune system can take several weeks to produce antibodies after an infection so there can be a long window of time between infection and detection. Gene-based diagnostic tests can measure the RNA of the HIV virus directly, greatly reducing the time it takes to diagnose the disease.

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  • Proteins and small molecules are commonly measured indirectly in diagnostics, through the use of antibodies (“immunodiagnostics”). Immunodiagnostic testing is the current “gold standard” for many diagnostic determinations. The application of RCAT™ in immunodiagnostics offers a significant opportunity for increasing the sensitivity of these tests.
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  • Allele Frequency Distortion (AFD), developed at the Yale University School of Medicine and licensed to MSI, is a method for identifying regions of DNA that differ between individuals who have a particular disease and those who do not.
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  • RCAT™ driven by DNA polymerase can replicate circular oligonucleotide probes with either linear or geometric kinetics under isothermal conditions.

    In the presence of two suitably designed primers, a geometric amplification occurs via DNA strand displacement and hyperbranching to generate 1012 or more copies of each circle in 1 hour.

    In addition to grossly amplifying a signal, this method—called Exponential-RCAT (E-RCAT™)—is adequately sensitive to detect point mutations in genomic DNA.

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  • Vision is able to look back in time to the Mesozoic Era and see the ghosts of dramatic changes in the genetic map of this model plant. His method will help scientists connect the known function of a gene in modern Arabidopsis to one in another species, thus extending the work from a common weed to the crops we depend on for survival. Read the rest of this entry »

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  • Human Gene Expression and Sequence Database

    LifeSeq® database is one of the world’s largest sources of genomic data. This commercial database of human gene expression and sequence information is used daily by scientists at more than 50 pharmaceutical research and development sites worldwide to identify therapeutic targets, to develop new approaches for diagnosing disease, and to understand the pharmacological and toxicological impact of new drugs on human tissues. Read the rest of this entry »

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  • Incyte and Oxford GlycoSciences (OGS) are currently using this proteomics technology platform in concert with Incyte’s gene expression microarrays and genomic databases to develop the LifeProt™ protein expression and sequence database. Read the rest of this entry »

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  • Protein Expression & Sequence Database

    LifeProt™ database contains protein expression and sequence information for a variety of human tissues, with links to related gene information in LifeSeq® database. Read the rest of this entry »

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