Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • Chromosome 7 accounts for approximately 5% of the human genome. It is estimated to be 136 centiMorgans (cM) in length and contains 170 million basepairs (170 Mb) of DNA. We are mapping and sequencing two targets along chromosome-7, one at 7q31.3, and the other at 7p14. Both are targets with little prior characterization other than the STS map, and as such, are representative of the bulk of the human genome. Read the rest of this entry »

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  • detecting-genetic-variation-in-bacterial-strains

    detecting-genetic1James M. Musser and his 40-person Laboratory of Human Bacterial Pathogenesis are taking a genome-scale approach to studying the causes of infectious disease. Musser and his team are using genome sequencing, DNA microarrays, and proteomics techniques to understand how bacteria cause disease. Musser hopes to find new gene targets that will lead to the development of new treatments and vaccines.  Read the rest of this entry »

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  • oncogenom

    oncogenom-11To most patients with cancer—and even to the physicians caring for them—the word “genomics” has little or no meaning. Many are vaguely aware that genomics has something to do with genes and may somehow relate to a genetic risk for cancer within families. However, when told that genomics entails an attempt to “fingerprint” their cancer, they immediately grasp the basic concept. Patients and physicians know that hardly a month passes without the popular press announcing a major breakthrough in our understanding of cancer. Read the rest of this entry »

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  • dna-repair-and-telomeres-announced-a-relationshipTo maintain genomic stability, mammalian cells require the action of five proteins encoded by paralogous genes to that of RAD51, a molecule involved in DNA repair, implying orquesrado operation of certain protective mechanisms.

    In previous work on RAD51 protein, essential in homologous recombination, has established its relationship to repair mechanisms. Their action, in response to gene damage depends on BRCA2 (protein related to breast cancer) and a series of proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), known as the RAD51 paralogues. The paralogy, understood as a degree of specialization adopted by horizontally related genes, can deliver a complete answer to the questions raised in this paper. Read the rest of this entry »

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  • new-regulation-for-a-particular-function-of-insulinInsulin is a paradigm of regulation and specific function. Essential anabolic hormone in the adult, seems to have a different role during embryonic development. A group from the Center for Biological Research, CSIC has been characterized step by step this new role. Insulin, as its precursor proinsulin and acting through insulin receptor hybrid with the growth factor insulin-like IGF-I, regulates the process of programmed cell death in the early stages of development of the nervous system stage where this process is, in turn, little studied. Read the rest of this entry »

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  • plasminogeo-activator-in-alzheimers-tissue

    The TAP (tissue plasminogen activator) is the main converter
    of plasminogen to plasmin in the brain, where it seems to have a beneficial
    role. In fact, it has been used as a drug to reduce brain damage in patients who
    have suffered strokes, as in the conversion of plasminogen to plasmin can
    dissolve the clots formed. However, you may also have neurotoxic effects, as
    reported already in 1998 a team from Harvard Medical School, noting that caused
    brain damage in mice the injection of the activator, and can be plasmin
    dependent or not.

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