Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images63Failures in the replication of genetic material during cell division leads to the activation of the checkpoint (checkpoint) of replication, conserved in eukaryotes. When it detects replicative stress cellular responses are activated to preserve the integrity of the genome, including the stabilization of replication forks, the activation of a specific transcriptional program and the slowing of the cycle to prevent entry into mitosis in the absence of adequate replication genetics. The principal effector in Schizosaccharomyces pombe Cds1 kinase is homologous to mammalian Chk2, which plays an essential role in stabilizing replication forks under stress. This kinase regulates events in brackets recombinogénicos stops and coordinates the resumption of replication when stress ceases and cells undergo an adaptation process. Read the rest of this entry »

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  • Human skin is a very complicated structure, constructed from various types of chemicals. It is an integrated system with interacting with each other chemical components. Human skin in 69-73% of water.

    Different layers of the skin vary considerably in its content: the share of the epidermis is about 10%, papillary layer – 71-72%. net dermis – about 61%. Normal cells activity is under constant ionic composition and pH of body fluids. In the water, readily soluble chemical compounds containing polar groups and capable of entering into the dipole-dipole interactions with water molecules or form with hydrogen bonds (-OH,-NH, C = 0): non-polar hydrocarbon molecules poorly or not soluble in it.
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  • The company will also implement next-generation high-throughput technologies for drug target discovery and pharmacogenomics applications. RCAT™ adds significant value in the genomics area. It can be used to localize DNA sequences to particular sites on chromosomes, to amplify and isolate DNA sequences without cloning in vivo, and to identify single base-pair genetic differences between individuals. MSI is developing biochips based on RCAT that perform ultra-high throughput Single-Nucleotide Polymorphism (SNP) analysis (both genotyping and haplotyping) for identification of disease genes and drug response genes. Designs for RCAT SNP Chips include arraying thousands of distinct patient samples or tens of thousands of SNPs on a single biochip. RCAT is the only amplification method that can perform direct molecular haplotype analysis. MSI will also utilize its Allele Frequency Distortion technology to rapidly identify genes linked to disease.

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  • MSI is developing an exciting new generation of research products based on RCAT. In collaboration with Amersham Pharmacia Biotech, we will be developing new methods and reagents for a wide range of research applications in the molecular biology laboratory. Application kits will provide everything needed by academic researchers and industrial scientists for RCAT including reagents, enzymes, control DNA templates, and instruction manuals that guide the researcher to success.

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  • While searching the radio sky, Alexander Wolszczan, professor of astronomy and astrophysics at Penn State University, discovered a new millisecond pulsar, PSR1257+12, with some exciting behavioral attributes. During the routine timing analysis associated with this discovery, Wolszczan recognized that PSR1257+12 seemed to “wobble” as it traveled through space. After further analysis, he was able to identify a pattern to the wobble. He proposed that there are two (perhaps three) planets orbiting PSR1257+12. Wolszczan believes that the planets’ gravitational pull is causing PSR1257+12′s unique behavior. When his findings are verified—and most of his peers expect that they will be —Wolszczan will go down in history as the first scientist to identify a planetary system beyond our own. Read the rest of this entry »

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  • The Center for Theory and Simulation in Science and Engineering at Cornell University (Cornell Theory Center) was established as an interdisciplinary research center with the mission to provide a national focal point for using high performance computing as a tool to accelerate the solution of scientific, engineering, and industrial problems, while at the same time advancing the basic and applied research that underlies that universal tool. High performance computing is an essential component of contemporary scientific research and engineering practice, providing a powerful and universal means of greatly extending the traditional methods of experimentation, theoretical analysis, and modeling. The use of high performance computing profoundly amplifies our technical imagination, because it enables us to explore new and unexpected avenues of reality and to visualize them in dramatic ways. For precisely these reasons, it is also an important vehicle for technological change, playing a key role in advancing the United States’ international competitive position and in protecting and improving the quality of life. Read the rest of this entry »

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  • Knowledge of the three-dimensional structure of a biological molecule can yield a wealth of information about its mode of action and direct the systematic design of pharmaceutical agents. Consequently structural studies have had a major impact in many areas of medicine. Read the rest of this entry »

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  • The core research in the NCRR center for Computational Biology Solutions is in protein folding, protein dynamics and bioinformatics. It provides a resource for a wide range of biological applications running on desktop to the highest-end computers. Read the rest of this entry »

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  • protein-characterizationAfter specific proteins are identified for further research, they are excised from the gel and treated with a succession of enzymes that cut amino acid chains into short polypeptides about 5-10 amino acids in length.

    The polypeptide fragments for each protein are then separated by capillary electrophoresis and analyzed using rapid-throughput mass spectrometry. At this point, we know the amino acid sequence of the polypeptide fragments, their mass, as well as post-translational modifications that occured such as glycosylation and phosphorylation. Read the rest of this entry »

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  • Annotation : A functional description of a clone, which may include identifying attributes such as locus name, keywords, and Medline references.

    BAC : Bacterial Artificial Chromosome; see cloning vector.

    BLAST  : The Basic Local Alignment Search Tool is a fast technique for detecting ungapped subsequences that match a given query sequence.

    BLIMPS : The BLocks IMProved Searcher is a search tool used to compare a DNA sequence against protein patterns in the Blocks database. Read the rest of this entry »

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