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In our earlier “A Fund” section opened with the analysis of a Spanish paper published in Nature (Ferris Marco et al., 2006). And we congratulabamos therefore it is still uncommon to see in that publication a study conducted entirely by Spanish investigators. It seems that our discussion had taken effect in the minds of so renowned editorial publication, and this month we have an equivalent opportunity to rejoice at the appearance of another article malignancy in Spanish on the British magazine par excellence. This time it’s a research on the regulation of a tumor suppressor locus. Read the rest of this entry »
Mammals are unable to synthesize metabolically various amino acids necessary for protein synthesis and should incorporate foods from the diet. These amino acids are called essential. Photosynthetic organisms can synthesize it. Has long been accepted that the metabolic pathways involved in the biosynthesis of amino acids in plants are identical to those in microorganisms. However, recent results indicate significant differences and a higher level of complexity due to the existence of multiple enzymes that are distributed in different subcellular compartments. Read the rest of this entry »
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Angela Nieto’s team has been working for 14 years in the functional analysis of the Snail gene family. After spending several years at the National Institute for Medical Research, London, Nieto is now a research professor at the Institute of Neurosciences of Alicante, where he heads a research group devoted to motion analysis and cellular plasticity. The first results of the group pointed to a fundamental role of Snail genes in embryonic smooth .
In this work, published in The EMBO Journal, Nieto group presents, in collaboration with the Hospital de San Juan de Alicante and the Imperial College of London, the first data that could result in the use of control of the expression of Snail as a diagnostic marker and target for anticancer therapies.
During embryonic development, the kidney epithelium originates from mesenchymal cells, whereas the opposite regression process has been associated with epithelial tumors and fibrosis leading to renal failure. It is known that Snail participates in the progression of such tumors, but so far no known role in development. This study has allowed recognition of Snail genes as a group of lowered expression during development and that this inhibition is correlated with the expression of cadherin-16. By contrast, Snail-induced activation leads to suppression of cadherin-16 through renal differentiation factors, which marked a new path of impaired kidney homeostasis. In turn, activation induces renal fibrosis in transgenic mice, while normal Snail expression remains silent.
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It is well known by all the activity of ion channels on the cell surface is essential for nerve signal transmission between neurons. Clearly, many factors regulate the activation and the level of traffic through these ion channels specific protein .
The group of Jose Ramon Naranjo, at the National Center for Biotechnology, has spent years focussing on the different mechanisms of regulation of gene expression in neurons in response to external signals that induce membrane depolarization. In these complex networks of control, the role of calcium and potassium channels focuses the latest hospitality group.
In this paper just published in The Journal of Biological Chemistry, the authors try to unravel the effect of the interaction of the protein DREAM (DRE sites antagonist modulator) with GRK2 and GRK6 kinases. Repressor DREAM is a calcium-dependent transcription in the nucleus and a regulator of trafficking of potassium channels in cell membranes. The interaction of DREAM with kinases occurs by phosphorylation. The experiments have uncovered that this reaction occurs specifically on serine at position 95 of the protein but no effect on repressor activity of DREAM. Interestingly, when this amino acid serine is mutated to aspartic acid, DREAM blocks membrane expression of Kv4.2 potassium channel.
Well, all these repressive effects and deregulation appear to be mediated, in turn, by cations Ca2 +, since treatment with calcineurin inhibitors block the potassium channels by interaction with DREAM and DREAM dephosphorylates complex in vitro.
AKR1B10 is a aldocetoreductasa (AKR) especially interesting for two reasons: it is overexpressed in lung cancer and precancerous lesions of smokers and becomes very efficient, the retinal to retinol, retinal reductase being the most active among AKR. Researchers from the Universitat Autònoma de Barcelona, IBMB, IRB Barcelona, and Universidade De Vigo CRQT propose that both features could be related through the alteration of the signaling pathway of retinoic acid. This compound, synthesized by successive oxidation of retinol (vitamin A) to retinal, and thence to acid molecule is a potent regulator of differentiation celular.Una AKR1B10 high expression, potentially induced by snuff, would result in a significant decrease retinal cell levels and, consequently, retinoic acid, which could lead to lack of differentiation, and induce cancer cell proliferation and . Read the rest of this entry »
Colorectal cancer is a leading cause of cancer death worldwide. Most of these tumors as benign lesions, but a small proportion may progress to malignant stages to accumulate genetic alterations in oncogenes and tumor suppressor genes. It is estimated that between 30 and 50% of people over age 60 may develop these benign adenomas. Colorectal cancer is in first position of the record of most common cancers in Spain and causes more than half a million deaths each year worldwide. The team’s work Batlle on tumor initiation and progression of it, from the early stages until the formation of aggressive tumors, has discovered and examined cellular and animal experimental models that mimic this devastating disease, with the ultimate goal of power design new diagnostic and therapeutic tools. Read the rest of this entry »
Many studies in the yeast Saccharomyces transcriptomic in analyzing the gene expression program in a variety of conditions. Most if not all the cited studies analyzed only the different levels of mRNA by conventional genomic techniques. Indeed, in many cases implicitly assumes that the levels of each mRNA are a direct consequence of the action of one or several transcriptional regulators. This does not take into account that mRNA levels depend both on its rate of synthesis and the degradation. This study, ‘paper of the week “in the journal J. Chem, is a collaboration between two groups at the universities of Lleida and Valencia, under the responsibility of Henry Smith and Jose Enrique Pérez-Ortín, respectively. Read the rest of this entry »
Understanding the biology of aging and therapeutic approach to pathologies associated with its development are facilitated by the study of syndromes of accelerated aging or progeria. These syndromes are characterized by early onset of physiological changes normally associated with old age.Progeroid syndromes, Werner’s syndrome or progeria of the adult, are caused by defects in various systems involved in maintaining the integrity of genetic material. By contrast, the progeroid laminopatías are caused by defects in components of the nuclear envelope. Read the rest of this entry »
The processes of metastasis, associated with 90% of cancer deaths, are a series of chained steps where the primary tumor invades surrounding tissues and just spreading throughout the body. One of the first tissues to suffer metastasis are the lymph nodes surrounding the tumor. Manel Esteller’s group has recently published an article in PNAS conducted in the National Cancer Research Center (CNIO), explaining how tumor cells escape from their original location to the lymph nodes. Read the rest of this entry »
The p53 tumor suppressor gene regulates the expression of p53-induced genes (PIG: p53 induced genes) that initiate apoptosis. The PIG3 or TP53I3 is the only member of the superfamily of dehydrogenases / reductases medium chain induced p53 proapoptotic be used as a marker. Although it is well known PIG3 participation in the apoptotic pathway or protein or its mechanism of action have been well characterized. Read the rest of this entry »