Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • Gene-Based Diagnostics Through RCAT™—Fast and Accurate
    Gene-based diagnostic tests are the fastest growing segment of the in vitro diagnostic market. They use the tools of molecular biology to identify nucleotide substitutions, deletions, or insertions in genes of medical interest. These tests provide several advantages over immunodiagnostic tests. For example, an immunodiagnostic HIV test, the current industry standard, detects the presence of HIV antibodies in blood. A person’s immune system can take several weeks to produce antibodies after an infection so there can be a long window of time between infection and detection. Gene-based diagnostic tests can measure the RNA of the HIV virus directly, greatly reducing the time it takes to diagnose the disease.

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  • Proteins and small molecules are commonly measured indirectly in diagnostics, through the use of antibodies (“immunodiagnostics”). Immunodiagnostic testing is the current “gold standard” for many diagnostic determinations. The application of RCAT™ in immunodiagnostics offers a significant opportunity for increasing the sensitivity of these tests.
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  • Unlimited DNA from a few cells.

    The
    growing trend to study disease and drug response at the molecular level
    has focused attention on DNA as a precious resource. Multiple Displacement
    Amplification (MDA) technology developed by MSI enables the first effective
    whole genome amplification method. The MDA method is a quantum leap over
    other currently available whole genome amplification methods, which are
    based on PCR
    The MSI MDA method rapidly amplifies the genome with comprehensive loci
    coverage and minimal bias between any loci, yielding 10+kb fragments in
    a simple, scalable reaction.

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  • rcatschematic2

    If your scientific goals include biomarker discovery, validation, or assessing drug response, coverage is vital. MSI offers ultra-multiplexed protein analysis designed to yield a comprehensive look at the biology underlying disease and drug response.
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  • Most amplified strands are converted to double-stranded DNA at end of reaction.

    mdaart6big

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  • After initial priming, an exponential cascade of branched amplification generates single-stranded template for on-going priming.

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  • the-cdc-aids-surveillance-case-definition1The clinical manifestations of HIV-1 infection are numerous, involving multiple organ systems and both infectious and neoplastic disease processes. From the beginning of the AIDS epidemic there was a need for a reportable case definition that was sensitive enough to monitor the epidemic but specific enough to exclude most cases that were not due to the then unknown agent. The first surveillance definition of an AIDS case used by the CDC was published in Morbidity and Mortality Weekly Roper (1) before HIV was identified, and therefore did not use HIV test results. AIDS was defined as “a case of a disease at least moderately predictive of a defect in cell-mediated immunity occurring in a person with no known cause for diminished resistance to that disease.” Read the rest of this entry »

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  • 71

    The structure and function of the central nervous system
    depends on movements, carefully controlled, the neurons in formation. One of the
    more complex neuronal migration and longer-range is given in the adult brain:
    the neuroblasts born in the sub ventricular zone migrate from these walls to the
    olfactory bulb. The question is how are oriented along a distance so large and
    so complex territories.

    A choral work responds to it, showing that the polarization of epithelial cells
    provides important information for the migration of new neurons. Signing of the
    Science article centers on the neurobiology and pathology of the University of
    California, Columbia, Tokyo and Cleveland, and the company Genentech. The
    Spanish contribution comes from the University of Valencia and Institutor de
    Neurociencias de Alicante, the latter through the work of Oscar Marin, who has
    been Youth Award for Science and Technology of the Universidad Complutense de
    Madrid and EMBO Award. Read the rest of this entry »

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  • 61

    The infectivity of a virus is determined by its ability to
    avoid the whole machinery of the host cell defense presented. Vaccinia virus
    (orthopoxvirus family of which belongs to the virus which causes smallpox)
    exhibits a surprising: it is able to induce motility of cells infected, as
    evidenced by work done in the Motility Laboratory Cellular Cancer Research in
    London. The first author of an article published in Science, Ferran Valderrama,
    is a Spanish left the ranks of the Institute of Biomedical Research August Pi I
    Sunyer, University of Barcelona and is currently studying in the English
    capital, the cellular mechanisms involved in cancer . Read the rest of this entry »

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  • 41Cancer is a genetic disease and epigenetics. The first thing is have ample evidence for years. Of the latter being generated every day more conclusive evidence. Demonstrate it has cost, despite the intense research carried out in this field and know the common feature in cancer cells provides the inactivation of tumor suppressor genes by mechanisms such as changes in the patterns of methylation of histones and DNA. Read the rest of this entry »

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