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  • In response to osmotic stress

    resize5Exposure of cells to stress results in the rapid activation of a highly conserved family of mitogen-activated protein kinase (MAPK), known as stress-activated protein kinases (SAPK). The activation of these MAPK in response to stress, both p38 in mammals, like Hog1 in yeast, is essential for generating adaptive responses necessary for cell survival. One of the most relevant functions of the yeast Hog1MAPK is to coordinate the transcriptional program required for cell survival upon osmotic stress. Previously, researchers at the University Pompeu Fabra had described different mechanisms regulated by the Hog1MAPK during the process of transcription initiation by osmotic stress (eg, modification of transcription factors and recruitment of specific promoters of the RNA polymerase complex II and Rpd3 histone deacetylase complex, Sin3). However, work recently published in the journal Molecular Cell, these researchers, in collaboration with a team of Harvard University show that the Hog1MAPK also controls the transcriptional elongation process of stress response genes.

    When a situation of stress, Hog1 is recruited in the coding regions of genes of stress, which is associated with components of the elongation complex and the RNA polymerase involved in the elongated process. The association of MAPK in the coding regions are performed through the 3 ‘ends of genes and is essential for the proper production of messenger RNA genes in response to osmotic stress. In conclusion, these researchers have shown that Hog1 behaves as a selective transcriptional elongation factor for those genes specifically induced in response to osmotic stress.

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