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  • Receptors, target genes and similarities to stem cells

    images80Colorectal cancer is a leading cause of cancer death worldwide. Most of these tumors as benign lesions, but a small proportion may progress to malignant stages to accumulate genetic alterations in oncogenes and tumor suppressor genes. It is estimated that between 30 and 50% of people over age 60 may develop these benign adenomas. Colorectal cancer is in first position of the record of most common cancers in Spain and causes more than half a million deaths each year worldwide. The team’s work Batlle on tumor initiation and progression of it, from the early stages until the formation of aggressive tumors, has discovered and examined cellular and animal experimental models that mimic this devastating disease, with the ultimate goal of power design new diagnostic and therapeutic tools.

    Recently, they have shown that EphB2 and EphB3 receptors, two target genes beta-catenina/TCF complex, suppress colorectal cancer progression beyond the early stages of tumor development. Most of these tumors silence the expression of EphB receptors around the adenoma-carcinoma transition, despite the presence of constitutive signaling by the route of Wnt.1, 2 present, try to decipher the molecular mechanism responsible for silencing expression of EphB2 and EphB3 in the advanced tumor.

    The research lines of this group fall squarely also on the apparent similarities that shows the behavior of stem cells and tumor cells. Thus, some of these works attempt to identify the relationship between normal cell renewal of intestinal epithelium, the determination of the characteristic of stem cell and cancer progression and its possible implications glimpse into future treatments based on the use of cells mother.3

    Published on December 2, 2012 · Filed under: Bioscience, News; Tagged as: , , , ,
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