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  • After the crux of the regulation

    images64Since the middle of last century was known that in vertebrates, meiosis and early embryonic divisions required polyadenylation and translational activation of maternal mRNA stored in the oocyte. However, it was not until the nineties when it began to elucidate the molecular mechanism of the expression of these mRNA, with the discovery of some of the major factors involved in the process.

    However, until now it had not determined how to produce temporary control of the translation of these mRNA so that the proteins encoded by different maternal mRNA stored in the cytoplasm is expressed only at certain times of meiotic or mitotic cycle, leading transitions from one phase to the next cycle independently and irreversible. These are processes that require precise control and well-defined cytoplasmic level.

    In a recent paper published in February this year in the prestigious journal Cell, the group of Raul Mendez, deciphered the code intervenes and determines when to activate these RNA messengers and identified the machinery that reads the code. 2 Next to this research, the work discussed in this A fund has been able to specify a code present in regions 3 ‘untranslated these maternal mRNA that determine when and how intensely they will translate to generate protein expression patterns of the factors which dictate the meiotic progression. Some work alongside some of the classics can analyze, develop and locate, with increasing precision, multiple levels of positive and negative regulation that ultimately lead to appropriate course between cell cycle phases. 3

    Published on November 24, 2012 · Filed under: Bioscience; Tagged as: , ,
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