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  • The Snail1 in osteoblasts is a regulator of bone mass

    melissa-pvc-sandalia5In this work, directed by Dr. Angela Nieto of the Instituto de Neurociencias de Alicante, it becomes evident that the first Snail1 transcriptional repressor of Runx2, which controls the activity of this protein complex during differentiation of osteoblasts.

    The bones are undergoing a process of constant remodeling throughout life, being the balance between its formation by osteoblasts and resorption by osteoclasts that determines bone mass. Among the factors that control this balance, the most critical seems to be the differentiation of osteoblasts. It is known that the main transcriptional regulator of osteoblast differentiation is Runx2. However, before this work is not known transcriptional regulators of Runx2 in osteoblasts.

    Previous evidence from this research group have shown that Snail1 activity regulates longitudinal bone growth by controlling the proliferation and differentiation of chondrocytes. From these results, using mice Snail ER T2 transgenic mice and cell cultures of osteoblasts, has demonstrated that not only Snail1 represses the transcription factor Runx2 but also differentiation genes of the vitamin D receptor (VDR) in osteoblasts. This has helped put Snail1 at the source of three essential routes for the control of bone remodeling and bone mass.

    Published on November 10, 2012 · Filed under: Bioscience; Tagged as: , ,
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