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  • TOR pathway and phosphatases

    images36The Ser / Thr protein phosphatases type 2C (PP2C) are a group of evolutionarily conserved enzymes. Other phosphatases unlikable, Whose specificity is based on the interaction Between A Few Regulatory Numerous catalytic subunits and subunits, most organisms express multiple isoforms of PP2C. The identification of the function of Each is a major challenge, sincere in Humans May act as tumor Suppressors.

    In this article, Gonzalez et al. PTC1 show, one of seven isoforms of PP2C in yeast S. cerevisiae, is required for proper signaling Through the TOR pathway, plays a key Which role in signaling from nutrients. The authors show attenuated That Lack of PTC1-through the signaling pathway, Affecting Practically Any of the Known targets (ribosomal gene expression, kernel entry of transcription Factors, etc.). .. The structure of the TOR pathway in S. cerevisiae is intricate and far from Being Fully defined. However, by epistasis analysis, it Appears That plays a role in PTC1-Tap42 interaction TIP41 NECESSARY for signal transmission.


    This interaction is Reduced in PTC1 mutants and this is at least partly Caused by Abnormally Low Levels of the protein TIP41. The Lack of PTC1 Does Not Affect TIP41 gene expression, But Dramatically Decreases the Stability of the protein. This Could Be Caused by Alterations in the pattern of phosphorylation of TIP41 detected in the mutant PTC1. Therefore it is the first time a type 2C phosphatase is related to the TOR pathway. Since this pathway is evolutionarily conserved, it is reasonable to speculate a similar role for PTC1 Counterparts in complex eukaryotes.

    Published on November 8, 2012 · Filed under: Bioscience; Tagged as: , , ,
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