Molecular Staging Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
  • Cytogen’s AxCell Biosciences and Molecular Staging to Investigate Biochips to Accelerate Mapping of Human Proteome

    Ultra-sensitive Prototype Assay for Prostate Cancer Marker Also Reported
    PRINCETON, N.J., Oct. 2 /PRNewswire/ — AxCell Biosciences Corporation, a subsidiary of Cytogen Corporation (Nasdaq: CYTO – news) and Molecular Staging, Inc., (MSI), Guilford, CT, initiated a scientific plan to investigate potential synergies between their technologies to map protein pathways more rapidly and efficiently. MSI’s Rolling Circle Amplification Technology (RCATTM) is a proprietary, highly sensitive and efficient amplification method for detecting the presence of target molecules micro-arrayed on a biochip. By combining AxCell’s domain-ligand interaction technology with MSI’s protein arrays, the two companies believe that they may be able to increase the rate of protein interaction measurements by 10 fold more than AxCell’s current rate of approximately 10,000 interactions per day.
    “By amplifying the signals used to detect protein interactions, we plan to measure many different targets simultaneously on a biochip,” explained John D. Rodwell, Ph.D., AxCell’s acting President and Chief Technical Officer. “The purpose of our joint effort is to evaluate the use of RCATTM technology with the same signaling molecules used in AxCell’s interaction measurements. Although our current proprietary process for measuring protein-to-protein interactions continues to function successfully at planned commercial scale, this combined technique could allow us to use less material and to operate more efficiently using readily available equipment. Potential benefits of combining these automatable technologies include ultra-high throughput affinity mapping and application of chip-based target arrays to protein expression.

    Ultra-sensitive PSA assay demonstrates promise
    “As part of a separate ongoing collaboration between Cytogen and MSI, the companies today also announced that they have achieved their first milestone — proof of principle for an ultra-sensitive serum assay for prostate-specific antigen (PSA), a widely used marker for the screening and detection of prostate cancer. Results using a panel of five antibodies to PSA indicate that the new RCAT-based assay has a sensitivity of more than 100 fold greater than existing commercial blood tests. Cytogen believes that an ultra-sensitive assay might lead to earlier detection of recurrent prostate cancer. The next step is the selection of one antibody for commercial development. The companies are also in the process of applying RCAT technology to establish proof of principle for an ultra-sensitive assay for prostate specific membrane antigen (PSMA), which Cytogen believes may have greater prognostic value than the PSA test alone.

    This week, Cytogen and Molecular Staging are scheduled to make separate presentations at the UBS Warburg Global Life Sciences Conference in New York City, where more scientific details of an ultra-sensitive PSA test will be discussed.

    AxCell profile
    AxCell Biosciences Corporation has begun a two-to-four year project to develop a comprehensive, proprietary database of human protein signaling pathways as a tool for identifying new drug targets. Aberrations in the interactions of proteins with one another are at the heart of the molecular basis for many diseases. Structural proteomics, or protein expression, measures the number and types of proteins present in normal and diseased cells. This approach is useful in defining the structure of proteins in a cell. Some of these proteins may be targets for drug discovery. However, the role of proteins in disease states remains to be defined. AxCell’s proteomics business is focused upon functional proteomics, the study of proteins’ biological activities. An important function of proteins is the transmission of signals using intricate pathways populated by proteins which interact with one another. Elucidating the role proteins play in these signaling pathways allows a better understanding of their function in cellular behavior and permits identification of potentially novel drug targets. Protein-protein interactions form the core of the Company’s Inter-functional Proteomic DatabaseTM (IFP). AxCell is offering the IFP Database to the pharmaceutical industry as a tool to accelerate the drug discovery process. AxCell Biosciences has agreed to enter into a collaboration with the Institute for Systems Biology to elucidate aberrations in protein signaling pathways underlying the metastatic spread of prostate cancer. For additional information on AxCell Biosciences, visit

    Molecular staging profile
    Molecular Staging Inc., is a privately held biotechnology company developing improved diagnostic tests for a variety of diseases and advanced tools for genetic analysis. MSI’s core technology, Rolling Circle Amplification Technology, is a highly sensitive and efficient nucleic acid amplification technique that can be used to better detect, diagnose, and stage disease. Its technologies enable the rapid identification of molecular abnormalities affecting genes, proteins, and small molecules. Information on MSI and its products is available from its web site at

    Cytogen profile
    Cytogen Corporation is a bio-pharmaceutical company in Princeton, NJ, whose mission is setting new standards in cancer care. Its two principal lines of business, proteomics and oncology, are built upon its expertise in antibodies and molecular recognition and are directed principally to development of novel products for the diagnosis, imaging, staging and treatment of prostate cancer and a proteomics-driven drug discovery platform. The Company’s cancer management franchise currently comprises four FDA-approved products: ProstaScint®, used to image the extent and spread of prostate cancer; BrachySeedTM implants for prostate cancer therapy; OncoScint CR/OV®, a diagnostic imaging agent for colorectal and ovarian cancer; and Quadramet®, for the relief of cancer-related bone pain. The Company has established a pipeline of product candidates based on its proprietary antibody and prostate-specific membrane antigen, or PSMA, technologies, and holds worldwide exclusive license to PSMA. Cytogen and its joint venture partner, Progenics Pharmaceuticals, are developing in vivo immunotherapies for prostate cancer based on PSMA. The Company also has U.S. marketing rights to the late-stage product candidate Combidex®, a magnetic resonance imaging agent being developed by Advanced Magnetics for the detection of lymph node metastases. For additional information visit

    This press release contains certain “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995. Information in this press release, which is not historical, is forward-looking and involves a number of risks and uncertainties. Investors are cautioned not to put any undue reliance on any forward-looking statement. The Company’s actual results may differ materially from the Company’s historical results of operations and those discussed in the forward-looking statements for various reasons, including, but not limited to the Company’s ability to carry out its business plan, successful development and commercial acceptance of its products, ability to fund development necessary for existing products and for the pursuit of new product opportunities, the risk of whether products result from development activities, protection of its intellectual property portfolio, ability to integrate in-licensed products, ability to establish and successfully complete clinical trials where required for product approval, the risk associated with obtaining the necessary regulatory approvals, dependence on its partners for development of certain projects, the ability to obtain foreign regulatory approvals for products and to establish marketing arrangements in countries where approval is obtained, and other factors discussed in the Company’s 1999 Form 10-K and from time-to-time the Company’s other filings with the Securities and Exchange Commission.

    Published on October 11, 2012 · Filed under: Press Release;
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