Molecular Staging Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
  • New Technology Increases the Availability of

    NEW
    HAVEN, April 16, 2002/– Molecular Staging Inc.
    (MSI) today announced the publication of a paper in
    today’s issue of Proceedings of the National Academy of
    Sciences of the United States of America (PNAS) that
    describes a method for generating millions of DNA copies
    from just a few cells.

     

    The
    increasing trend to study disease and drug response at the
    genetic level has focused attention on DNA as a precious
    resource.  Researchers
    need sufficient high quality DNA to address the rapid
    growth in both the volume and variety of genetic tests,
    yet typically the amount of DNA from individual patient
    samples is limited and the methods used to extract DNA are
    cumbersome.

     

    “MSI
    has developed the first effective method of extracting and
    amplifying the entire human genome approximately one
    million-fold in a few simple steps,” said Dr. Stephen
    Kingsmore, Chief Operating Officer of MSI. 
    “We believe the availability of this technology
    has the potential to transform the current practice of
    genetic testing.”

     

    In
    particular, MSI’s MDA technology enables:

    •  Virtually unlimited number of genetic tests per
      sample

    •  Use of samples such as buccal swabs, mouthwash,
      finger-prick,  etc.

    •  Use of DNA from alternative sources such as
      biopsies, needle aspirates, etc.                                                                                                                                        

    • An
      increase in the practice of archiving DNA for additional
      testing  or retesting

    The
    method is described in detail in the paper entitled
    Comprehensive Human Genome Amplification Using Multiple
    Displacement Amplification, PNAS, Volume 99 (8), 2002, pp
    5261-5266.

    “Earlier
    attempts to amplify the whole genome lead only to
    amplification of a subset of the genome, thus rendering
    these methods useless as a general tool for genetic
    analysis,” stated Dr. Michael Egholm, Vice President of
    Research at MSI, and co-author of the paper. 
    “The technology, multiple displacement
    amplification (MDA), is a substantial advancement over
    currently available whole genome amplification methods,
    rapidly amplifying the genome with comprehensive loci
    coverage, minimal bias between any loci and yielding 10+
    kb fragments in a simple, scalable reaction,” continued
    Dr. Egholm. 

     

    Molecular
    Staging has exclusively licensed MDA from Yale University.
    MSI is a privately held life science company developing a
    portfolio of proprietary technologies that are
    transforming the detection and measurement of proteins and
    nucleic acids.  MSI’s
    technologies, combined with sophisticated bioinformatics,
    broadly enable a wide range of products and services
    across multiple health care markets. 

    One of MSI’s core technologies is Rolling Circle
    Amplification Technology (RCATTM), an
    amplification process that has significant advantages in
    terms of sensitivity, multiplexing, dynamic range and
    scalability. MSI has exclusively licensed RCAT from Yale
    University. 

    Additional
    information about MSI can be found at www.molecularstaging.com.

    Published on October 9, 2012 · Filed under: Press Release;
    Comments Off on New Technology Increases the Availability of