Molecular Staging Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
  • Multiplexed Protein Profiling on Protein Chips Using Rolling Circle Amplification

    NEW HAVEN, April 18, 2002/– Molecular Staging Inc. (MSI) today announced the publication of a landmark paper in this month’s issue of Nature Biotechnology that describes a new approach to analyzing multiple proteins simultaneously on a glass chip microarray.

    The paper, entitled “Multiplexed Protein Profiling on Microarrays using Rolling Circle Amplification (RCAT),” describes a chip based proteomics discovery platform that employs RCAT to amplify signals from proteins in a highly multiplexed format.

    “A key unmet need for proteomics is the requirement to analyze multiple proteins simultaneously in order to get a comprehensive look at the biology underlying disease and drug response,” said Dr. Stephen Kingsmore, Chief Operating Officer of MSI. “Global patterns of protein expression have been shown to yield more biologically relevant and clinically useful information than assays of single proteins. However, currently available technologies either limit the number of proteins that can be analyzed simultaneously or they are expensive, difficult and time consuming.”

    The paper describes the first effective protein chip to measure 80 proteins simultaneously in a human sample.

    “Protein chips are emerging as a simple, easy to use platform for protein analysis,” said Dr. Kingsmore. “Until now, their widespread acceptance has been constrained by limits on the number of proteins that can be analyzed at acceptable levels of sensitivity. MSI’s chip based discovery platform using RCAT overcomes these issues and offers the thorough coverage needed by today’s drug discovery and development scientists.”

    MSI is using protein chips for biomarker discovery in disease and clinical trials with a number of academic and pharmaceutical leaders.

    MSI is a privately held life science company developing a portfolio of proprietary technologies that are transforming the detection and measurement of proteins and nucleic acids. MSI’s technologies, combined with sophisticated bioinformatics, broadly enable a wide range of products and services across multiple health care markets. One of MSI’s core technologies is Rolling Circle Amplification Technology (RCATTM), an amplification process that has significant advantages in terms of sensitivity, multiplexing, dynamic range and scalability. Another core technology is Multiple Displacement Amplification (MDA), which enables the first effective whole genome amplification. MSI has exclusively licensed RCAT and MDA from Yale University. Additional information about MSI can be found at www.molecularstaging.com.

    Published on October 9, 2012 · Filed under: Press Release;
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