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  • Subunit composition of Srb/Mediator-like complexes

    Subunit composition of Srb/Mediator-like complexes

    The subunits of yeast, human and mouse SRB/mediator-like complexes are compared. Identical or orthologous subunits are marked by tan boxes and connected by lines. Numbers indicate subunit size in kDa. Soh1 has not yet been confirmed as a component of the yeast Srb/Mediator.


    Yeast Human Mouse
    SRB/
    Mediator
    TRAP/
    SMCC
    DRIP ARC CRSP NAT hMED mMed Notes
    240 250 250
    Srb8 230
    230 240 240
    Srb9 160a
    Nut1 160b
    220 205 205 200 TRAP220 binds hormone receptors
    Rgr1 170 150 150 150 150 110 Human Rgr1, also called EXLM1
    150a 140
    Gal11
    150b 130 130 130 Sur2 hSur2 interacts w/E1A & VP16
    105 ARC105, also called TIG1
    100 100 100 100
    Sin4
    97 97 95 96a
    95 92 96b
    Srb4
    93 92 85 90
    80 77 77 77 78 TRAP80 interacts w/ VP16, p53
    78
    70 70 70 DRIP/ARC/CRSP70 similar to TFIIS
    Med1 70
    Srb10 Cdk8 Cdk8 Cdk8 CTD kinase activity
    Med2 45 45
    Pgd1 37
    37 34
    Srb5
    36/28 36 36 34
    Med7 hMed7 34 34 33 hMed7 hMed7 mMed7
    Srb11 cyclin C cyclin C cyclin C Cyclin partner of Srb10/Cdk8
    Med6 hMed6 33 33 mMed6 Involved in activation in yeast
    TRFP TRFP Homolog of TRF-prox. protein
    Med4 30
    Med8 32 28b
    24 23
    Rox3
    22 22
    Srb2 21
    Srb7 hSrb7 hSrb7 mSrb7 Essential in yeast and mouse
    Soh1 hSoh1
    Nut2 hNut2 hNut2
    Cse2
    12
    Med11
    Srb6
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