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  • New regulation for a particular function of insulin

    new-regulation-for-a-particular-function-of-insulinInsulin is a paradigm of regulation and specific function. Essential anabolic hormone in the adult, seems to have a different role during embryonic development. A group from the Center for Biological Research, CSIC has been characterized step by step this new role. Insulin, as its precursor proinsulin and acting through insulin receptor hybrid with the growth factor insulin-like IGF-I, regulates the process of programmed cell death in the early stages of development of the nervous system stage where this process is, in turn, little studied.

    In a recent collaboration between the Centre for Molecular Biology of the CSIC and the University of Heidelberg is a further step, to characterize the mechanisms of regulation of proinsulin levels required for embryonic function. The embryonic proinsulin transcript differs from the pancreas in an extension of 32 nucleotides at its 5 ‘untranslated, which contains two additional initiation triplet AUG proinsulin, located later in the messenger. The presence of these triplets drastically reduces the amount of proinsulin translation, compared with pancreatic transcript. The regulation of translation at a reduced level seems to be essential to allow the process of cell death necessary for proper development. A slight excess of proinsulin, added exogenously, cause birth defects in the neural tube.

    Published on August 26, 2012 · Filed under: Bioscience, Research Reagents; Tagged as: , , , , ,
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