Molecular Staging Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
  • The mitofusin 2 in mitochondrial energization

    the-mitofusin-2-in-mitochondrial-energizationThe mitofusin 2 (Mfn2) is a mitochondrial fusion protein whose expression decreased in skeletal muscle is related to processes such as obesity and type 2 diabetes and its deficiency decreases oxygen consumption, mitochondrial membrane potential and oxidation of glucose. In addition, he described an antiproliferative role in vascular disorders, and certain mutations in the Mfn2 gene, encoding this protein cause neurological disease Charcot-Marie-Tooth (CMT) type 2A, a hereditary sensorimotor neuropathy classified as rare.

    Therefore, the study of the regulation of gene expression is of great interest, as demonstrated by this work done at the University of Barcelona and the Institute for Biomedical Research (IRBB-PCB) in the same city, which shows that loss of function of Mfn2 inhibited the oxidation of pyruvate, glucose and fatty acids, and reduces the mitochondrial membrane potential, whereas the recovery of the function of Mfn2 increases glucose oxidation and membrane potential mitochondria.

    Their results concerning the effect of inhibition and overexpression of Mfn2 on mitochondrial metabolism indicate that Mfn2 is involved in the regulation of expression of the complex of oxidative phosphorylation system and, therefore, in the process of mitochondrial energization.

    Published on August 23, 2012 · Filed under: Bioscience; Tagged as: , , , ,
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