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  • A new protein coordinates cytokinesis

    image199Understanding the control of cell division is one of the great challenges of biology, for its implications in the generation of multicellular organisms and in proliferative processes such as oncogenesis. The tool to achieve such knowledge used by the groups of the Andalusian Center for Developmental Biology, CSIC, Seville, and the Cancer Research Center of Salamanca signing this collaboration is the fission yeast Schizosaccharomyces pombe, which analyzes the mechanisms coordinate control various processes involved in cellular mitosis, and cytokinesis.

    In the fission yeast, this mechanism involves the constriction of an act myosin ring, which was triggered by a cascade of kinases, which coordinates the end of mitosis with cytokinesis. This work has identified a new protein, Etd1p needed to trigger the constriction in the model organism. During the interface is located at the ends of the cells, whereas mitosis is translocated to the middle region and coincide with cytokinesis, binds to the act myosin ring by association with Cdc15p, a protein kinase essential part of a group late mitotic proteins. The study results suggest that mitotic activation Etd1p coordinates of the kinase cascade with the initiation of act myosin ring constriction. After cytokinesis is degraded by coupling the inactivation of the SIN cascade with the completion of cytokinesis.

    Published on August 20, 2012 · Filed under: Bioscience, News; Tagged as: , , , ,
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