Molecular Staging

Molecular Staging is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.

  • images24Structural Proteomics Group, Institute of Biomedicine of Valencia (CSIC) develops several years studies on the evolution and functional characteristics of different proteins from the venom of snakes, from the Mediterranean region. These proteins selectively block the function of cell surface receptors of the integrin family.

    Becoming available and genomic libraries of tissues and many different agencies. In this case, researchers in Valencia have been cloned and sequenced cDNA fragments of the venom-producing gland in Cerastes Viper and short disintegrins encoding and subunits of dimeric disintegrins. Read the rest of this entry »

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  • images23Cancer, such as biological process that goes beyond the laws of development and cellular growth, requires relocation process and investigate molecular mechanisms that lead to uncontrolled cell division, genomic instability and tumor development. The identification of these new patterns of growth and development can be very important to understand and combat processes tumorogĂ©nesis.1 It appears from research such as referenced here, the Cdc6 and other cellular components are joined, forming complexes prerreplicativos before initiated DNA duplication. Read the rest of this entry »

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  • images22In our earlier “A Fund” section opened with the analysis of a Spanish paper published in Nature (Ferris Marco et al., 2006). And we congratulabamos therefore it is still uncommon to see in that publication a study conducted entirely by Spanish investigators. It seems that our discussion had taken effect in the minds of so renowned editorial publication, and this month we have an equivalent opportunity to rejoice at the appearance of another article malignancy in Spanish on the British magazine par excellence. This time it’s a research on the regulation of a tumor suppressor locus. Read the rest of this entry »

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  • images21Mammals are unable to synthesize metabolically various amino acids necessary for protein synthesis and should incorporate foods from the diet. These amino acids are called essential. Photosynthetic organisms can synthesize it. Has long been accepted that the metabolic pathways involved in the biosynthesis of amino acids in plants are identical to those in microorganisms. However, recent results indicate significant differences and a higher level of complexity due to the existence of multiple enzymes that are distributed in different subcellular compartments. Read the rest of this entry »

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  • 7All processes of gene activity are accompanied by alterations in DNA helical tension. Consequently, the double helix twists on itself, or supercoiled to remain stable throughout its length. This tension may be very high during the processes of transcription and DNA replication, since the two strands, always linked in the double helix, are forced to separate, in part or total. Due to the enormous length and the large condensation of DNA molecules in chromosomes, the coil voltage can not dissipate spontaneously. Read the rest of this entry »

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  • 6Efforts to characterize the process of apoptosis, or programmed cell death, are probably one of the clearest examples to represent the inherent complexity of regulatory mechanisms and interactions between enzymes, signals and various growth factors in a cell. Among these mechanisms, the role played by the kinase p38aMAP object of interest is the group of the Faculty of Pharmacy of the Universidad Complutense de Madrid, coordinated by Almudena Porras. In a paper published in the online edition of Cell Signal, this team has characterized cell lines derived from cardiomyocytes and mouse embryonic fibroblasts deficient in p38aMAP normal, with the aim to detect different responses to the process of apoptosis. Read the rest of this entry »

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  • 5The transition between each of the phases of the cell cycle is controlled by phosphorylation processes carried out by enzymes known as cyclin dependent kinase (CDK). In mammalian cells, the enzyme bound to CDK2 cyclin A acts as the main promoter of the transition from G1 to S phase cell cycle progression and S phase, when DNA replication. Thus, the cyclin A-CDK2 complex binds to a large number of regulatory proteins at different times during cell cycle progression. Read the rest of this entry »

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  • 4Catalan researchers of the Institute for Biomedical Research of Bellvitge in Barcelona and the Beatson Institute for Cancer Research in Glasgow, published in Cell the discovery of Tigar, the first gene involved in the antioxidant cellular mechanism associated with the prevention of tumor formation. This paper shows that low concentrations of p53 protein are sufficient to activate the gene Tigar. Read the rest of this entry »

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  • 3A rare disease characterized by premature aging is modeled after a group of Spanish scientists to better understand the relationship between cancer, genes and aging. This is Werner syndrome, an inherited disorder characterized by premature aging of the individual, genomic instability and an increased incidence of tumors. The study was conducted jointly by researchers at the Hospital Clinic of Barcelona, Biomedical Research Center of Navarre, the National Institute on Aging U.S., and the group of Manel Esteller of the CNIO. Read the rest of this entry »

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  • 2Embryonic development and morphogenesis of individual organs are common schemes based processes. In them, groups of undifferentiated cells, they initiate a series of complex interactions with internal and external signals, in order to establish patterns that direct cells to their subsequent proliferation, differentiation, coordinated morphological change and migration. This seemingly elementary, requires the integration of a series of activations and changes in the expression levels of a few basic genes. Two mechanisms are paramount in this general scheme: the proper control of temporal and spatial activation patterns of cell signaling, and the union of these patterns with cellular effectors that activate cellular responses in terms of gene activity or cell morphology. Read the rest of this entry »

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